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Descriptor English: Growth Differentiation Factor 1
Descriptor Spanish: Factor 1 de Diferenciación de Crecimiento
Descriptor factor 1 de diferenciación del crecimiento
Entry term(s) GDF-1
Scope note: Factor de diferenciación del crecimiento que desempeña un papel en la génesis de la asimetría izquierda-derecha durante el desarrollo de los vertebrados. Su función se demuestra en  RATONES, en los que la pérdida del factor 1 de diferenciación del crecimiento da a lugar a la isomería derecha-izquierda de los órganos viscerales. La pérdida de la función del factor 1 del crecimiento en seres HUMANOS heterocigotos se asocia con CARDIOPATÍAS CONGÉNITAS y TRANSPOSICIÓN DE LOS GRANDES VASOS.
Descriptor Portuguese: Fator 1 de Diferenciação de Crescimento
Descriptor French: Facteur-1 de croissance et de différenciation
Entry term(s): GDF-1
Tree number(s): D12.644.276.954.300.100
D12.644.276.954.550.100
D12.776.467.942.300.100
D12.776.467.942.550.100
D23.529.942.300.100
D23.529.942.550.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D055452
Scope note: A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2009; GROWTH DIFFERENTIATION FACTOR 1 was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2005-2008
History Note: 2009(2005)
DeCS ID: 53139
Unique ID: D055452
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2009/01/01
Date of Entry: 2008/07/08
Growth Differentiation Factor 1 - Preferred
Concept UI M0517745
Scope note A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS.
Preferred term Growth Differentiation Factor 1
Entry term(s) GDF-1



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