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Descriptor English: Cyclin-Dependent Kinase 8
Descriptor Spanish: Quinasa 8 Dependiente de Ciclina
Descriptor cinasa 8 dependiente de ciclina
Scope note: Cinasa dependiente de ClCLlNA C que es un componente importante del complejo mediador. La enzima es activada por su interacción con la CICLINA C y desempeña un papel en la regulación transcripcional mediante la fosforilación de la ARN POLIMERASA II. 
Descriptor Portuguese: Quinase 8 Dependente de Ciclina
Descriptor French: Cyclin-Dependent Kinase 8
Entry term(s): Cdk8 Cyclin Dependent Kinase
Cdk8 Cyclin-Dependent Kinase
Cdk8 Protein Kinase
Cell Division Protein Kinase 8
Cyclin Dependent Kinase 8
Cyclin-Dependent Kinase, Cdk8
Kinase, Cdk8 Cyclin-Dependent
Kinase, Cdk8 Protein
Protein Kinase, Cdk8
Tree number(s): D05.500.374.500
D08.811.913.696.620.682.700.646.500.968
D12.776.157.057.072.500
D12.776.167.200.548
D12.776.476.024.388.500
D12.776.476.563.646.500.968
D12.776.660.551.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D056850
Scope note: A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is activated by its interaction with CYCLIN C and plays a role in transcriptional regulation by phosphorylating RNA POLYMERASE II.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.22
Previous Indexing: Cyclin-Dependent Kinases (1995-2009)
Public MeSH Note: 2010
History Note: 2010
DeCS ID: 53575
Unique ID: D056850
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/03/30
Cyclin-Dependent Kinase 8 - Preferred
Concept UI M0529506
Scope note A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is activated by its interaction with CYCLIN C and plays a role in transcriptional regulation by phosphorylating RNA POLYMERASE II.
Preferred term Cyclin-Dependent Kinase 8
Entry term(s) Cdk8 Cyclin Dependent Kinase
Cdk8 Cyclin-Dependent Kinase
Cdk8 Protein Kinase
Cell Division Protein Kinase 8
Cyclin Dependent Kinase 8
Cyclin-Dependent Kinase, Cdk8
Kinase, Cdk8 Cyclin-Dependent
Kinase, Cdk8 Protein
Protein Kinase, Cdk8



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