DeCS

Descriptor English:

Mediator Complex

Descriptor Spanish:

Complejo Mediador

Spanish from Spain

Descriptor

complejo mediador

Scope note:

Gran complejo proteico que actúa como una proteína adaptadora de señalización que posibilita la comunicación entre los diversos componentes funcionales y reguladores de la TRANSCRIPCIÓN GENÉTICA incluidos la ADN POLIMERASA II, FACTORES GENERALES DE TRANSCRIPCIÓN y FACTORES DE TRANSCRIPCIÓN unidos a ELEMENTOS POTENCIADORES GENÉTICOS situados en el extremo 5'. El complejo mediador se estudió originalmente en LEVADURAS donde se identificaron al menos 21 subunidades. Muchas de las subunidades de las levaduras son homólogas a las proteínas de los organismos superiores que se encuentran asociadas con receptores nucleares específicos, tales como RECEPTORES DE HORMONA TIROIDEA y RECEPTORES DE VITAMINA D.

Descriptor Portuguese:

Complexo Mediador

Descriptor French:

Complexe médiateur

Entry term(s):

Mediator Like Complex
Mediator Like Complexes
Mediator Transcription Complex
Mediator-Like Complex
Mediator-Like Complexes
TR-Associated Protein (TRAP) Complex
TRAP (Thyroid Hormone Associated Protein) Complex
Thyroid Hormone Associated Protein Complex
Thyroid Hormone-Associated Protein Complex

Tree number(s):

D05.500.374
D12.644.360.024.309
D12.776.157.057.072
D12.776.476.024.388
D12.776.660.551

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D056892

Scope note:

A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Previous Indexing:

RNA Polymerase II (1994-2009)
Transcription Factors (1994-2009)

Public MeSH Note:

2010; TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX were indexed under TRANSCRIPTION FACTORS 2003-2009

History Note:

2010; for TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX use MEDIATOR COMPLEX SUBUNIT 1 2003-2009

Concept UI	M0533184
Scope note	A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.
Preferred term	Mediator Complex
Entry term(s)	Mediator Transcription Complex

Concept UI	M0533375
Preferred term	Thyroid Hormone-Associated Protein Complex
Entry term(s)	TR-Associated Protein (TRAP) Complex TRAP (Thyroid Hormone Associated Protein) Complex Thyroid Hormone Associated Protein Complex

Concept UI	M0533244
Preferred term	Mediator-Like Complexes
Entry term(s)	Mediator Like Complex Mediator Like Complexes Mediator-Like Complex

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