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Descriptor English: Mediator Complex
Descriptor Spanish: Complejo Mediador
Descriptor Portuguese: Complexo Mediador
Descriptor French: Complexe médiateur
Entry term(s): Mediator Like Complex
Mediator Like Complexes
Mediator Transcription Complex
Mediator-Like Complex
Mediator-Like Complexes
TR-Associated Protein (TRAP) Complex
TRAP (Thyroid Hormone Associated Protein) Complex
Thyroid Hormone Associated Protein Complex
Thyroid Hormone-Associated Protein Complex
Tree number(s): D05.500.374
D12.644.360.024.309
D12.776.157.057.072
D12.776.476.024.388
D12.776.660.551
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D056892
Scope note: A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: RNA Polymerase II (1994-2009)
Transcription Factors (1994-2009)
Public MeSH Note: 2010; TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX were indexed under TRANSCRIPTION FACTORS 2003-2009
History Note: 2010; for TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX use MEDIATOR COMPLEX SUBUNIT 1 2003-2009
DeCS ID: 53573
Unique ID: D056892
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/03/30
Mediator Complex - Preferred
Concept UI M0533184
Scope note A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.
Preferred term Mediator Complex
Entry term(s) Mediator Transcription Complex
Thyroid Hormone-Associated Protein Complex - Narrower
Concept UI M0533375
Preferred term Thyroid Hormone-Associated Protein Complex
Entry term(s) TR-Associated Protein (TRAP) Complex
TRAP (Thyroid Hormone Associated Protein) Complex
Thyroid Hormone Associated Protein Complex
Mediator-Like Complexes - Narrower
Concept UI M0533244
Preferred term Mediator-Like Complexes
Entry term(s) Mediator Like Complex
Mediator Like Complexes
Mediator-Like Complex



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