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Descriptor English: Peroxisomal Bifunctional Enzyme
Descriptor Spanish: Enzima Bifuncional Peroxisomal
Descriptor enzima bifuncional peroxisómica
Entry term(s) enzimas peroxisómicas bifuncionales
Scope note: Proteína monomérica localizada en los peroxisomas del hígado, que contiene dos dominios enzimáticamente activos; un dominio enoil-CoA hidratasa/3,2-trans-enoil-CoA isomerasa, y un dominio (S)-3-hidroxiacil-CoA deshidrogenasa. La enzima es estereoespecífica con respecto a la metabolización de los dobles enlaces cis y trans. Es complementada por la PROTEÍNA MULTIFUNCIONAL PEROXISÓMICA-2, que tiene la estereoespecificidad opuesta.
Descriptor Portuguese: Enzima Bifuncional do Peroxissomo
Descriptor French: Enzyme bifonctionnelle péroxysomique
Entry term(s): 2-Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Dehydrogenase-delta 3, delta 2-Enoyl-CoA Isomerase
Bifunctional Enzyme, L-Peroxisomal
Bifunctional Enzyme, Peroxisomal
Dehydrogenase, Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA
Enoyl CoA Hydratase 3 Hydroxyacyl CoA Dehydrogenase
Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA Dehydrogenase
Hydratase-3-Hydroxyacyl-CoA Dehydrogenase, Enoyl-CoA
Hydratase-Dehydrogenase-Epimerase, Peroxisomal
L Bifunctional Enzyme
L Peroxisomal Bifunctional Enzyme
L-Bifunctional Enzyme
L-Peroxisomal Bifunctional Enzyme
Peroxisomal Bifunctional Enzymes
Peroxisomal Hydratase Dehydrogenase Epimerase
Peroxisomal Hydratase-Dehydrogenase-Epimerase
Peroxisomal Multifunctional beta Oxidation Protein
Peroxisomal Multifunctional beta-Oxidation Protein
Peroxisomal Trifunctional Enzyme
Peroxisomal-Bifunctional Enzymes
Tree number(s): D08.811.399.475.400.349.500
D08.811.520.241.300.250.750
D08.811.641.781
D08.811.682.047.820.150.207.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D063994
Scope note: A monomeric protein found in liver peroxisomes that contains two enzymatically active domains; an enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase domain, and an (S)-3-hydroxyacyl-CoA dehydrogenase domain. The enzyme is stereospecific with regards to how cis and trans double bonds are metabolized. It is complemented by PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2, which has the opposite stereospecificity.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.2.1.17
Public MeSH Note: 2014; PEROXIISOMAL-BIFUNCTIONAL ENZYME was indexed under ENOYL-COA-HYDRATASE, ISOMERASES, 3-HYDROXYACYL COA DEHYDROGENASES, and MULTIENZYME COMPLEXES 1986-2013
History Note: 2014
DeCS ID: 55271
Unique ID: D063994
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/09
Revision Date: 2016/04/18
Peroxisomal Bifunctional Enzyme - Preferred
Concept UI M0578941
Scope note A monomeric protein found in liver peroxisomes that contains two enzymatically active domains; an enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase domain, and an (S)-3-hydroxyacyl-CoA dehydrogenase domain. The enzyme is stereospecific with regards to how cis and trans double bonds are metabolized. It is complemented by PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2, which has the opposite stereospecificity.
Preferred term Peroxisomal Bifunctional Enzyme
Entry term(s) 2-Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Dehydrogenase-delta 3, delta 2-Enoyl-CoA Isomerase
Bifunctional Enzyme, L-Peroxisomal
Bifunctional Enzyme, Peroxisomal
Dehydrogenase, Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA
Enoyl CoA Hydratase 3 Hydroxyacyl CoA Dehydrogenase
Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA Dehydrogenase
Hydratase-3-Hydroxyacyl-CoA Dehydrogenase, Enoyl-CoA
Hydratase-Dehydrogenase-Epimerase, Peroxisomal
L Bifunctional Enzyme
L Peroxisomal Bifunctional Enzyme
L-Bifunctional Enzyme
L-Peroxisomal Bifunctional Enzyme
Peroxisomal Bifunctional Enzymes
Peroxisomal Hydratase Dehydrogenase Epimerase
Peroxisomal Hydratase-Dehydrogenase-Epimerase
Peroxisomal Multifunctional beta Oxidation Protein
Peroxisomal Multifunctional beta-Oxidation Protein
Peroxisomal Trifunctional Enzyme
Peroxisomal-Bifunctional Enzymes



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