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Descriptor English: Autophagy-Related Protein 7
Descriptor Spanish: Proteína 7 Relacionada con la Autofagia
Descriptor proteína 7 relacionada con la autofagia
Entry term(s) enzima ATG7 modificadora-activadora similar a ubicuitina
enzima E1 ATG7 activadora de la ATG12
enzima E1 ATG7 que activa ATG12
enzima modificadora-activadora similar a ubicuitina ATG7
proteína ATG7
proteína ATG7 similar a la enzima modificadora-activadora de ubicuitina
proteína similar a la enzima E1 activadora de ubicuitina
proteína similar a la enzima modificadora-activadora de ubicuitina ATG7
Scope note: Proteína relacionada con la autofagia similar a una de las ENZIMAS UBICUITINA-ACTIVADORAS (la ENZIMA E1 ACTIVADORA DE LA UBICUITINA). Actúa en el transporte desde el CITOPLASMA a las VACUOLAS (Cvt) y en la AUTOFAGIA mediante la activación de la PROTEÍNA ATG12 para su conjugación con la PROTEÍNA ATG5, así como en la conjugación de la FAMILIA DE PROTEÍNAS ATG8 con fosfatidiletalonamina para la asociación de ATG8 con las vesículas Cvt y las membranas de los AUTOFAGOSOMAS. También es necesaria para la respuesta a la privación de nitrógeno en levaduras, la DEGRADACIÓN MITOCONDRIAL y la muerte celular por autofagia inducida por la inhibición de la CASPASA 8.
Descriptor Portuguese: Proteína 7 Relacionada à Autofagia
Descriptor French: Protéine-7 associée à l'autophagie
Entry term(s): ATG12 Activating Enzyme E1 ATG7
ATG12-Activating Enzyme E1 ATG7
ATG7 Protein
Autophagy Related Protein 7
Ubiquitin Activating Enzyme E1 like Protein
Ubiquitin Like Modifier Activating Enzyme ATG7
Ubiquitin-Activating Enzyme E1-like Protein
Ubiquitin-Like Modifier-Activating Enzyme ATG7
Tree number(s): D12.776.094.399
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071193
Scope note: An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 6.2.1.45
Previous Indexing: Microtubule-Associated Proteins (2005-2016)
Ubiquitin-Activating Enzymes (2006-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56559
Unique ID: D000071193
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/25
Autophagy-Related Protein 7 - Preferred
Concept UI M000613486
Scope note An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.
Preferred term Autophagy-Related Protein 7
Entry term(s) ATG12 Activating Enzyme E1 ATG7
ATG12-Activating Enzyme E1 ATG7
ATG7 Protein
Autophagy Related Protein 7
Ubiquitin Activating Enzyme E1 like Protein
Ubiquitin Like Modifier Activating Enzyme ATG7
Ubiquitin-Activating Enzyme E1-like Protein
Ubiquitin-Like Modifier-Activating Enzyme ATG7



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