| Descriptor English: | Autophagy-Related Protein-1 Homolog | ||||||
| Descriptor Spanish: |
Homólogo de la Proteína 1 Relacionada con la Autofagia
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| Descriptor Portuguese: | Proteína Homóloga à Proteína-1 Relacionada à Autofagia | ||||||
| Descriptor French: | Homologue de la protéine-1 associée à l'autophagie | ||||||
| Entry term(s): |
Autophagy Related Protein 1 Homolog Serine Threonine Protein Kinase ULK1 Serine-Threonine Protein Kinase ULK1 ULK1 Protein Unc 51 Like Autophagy Activating Kinase 1 Unc 51 Like Kinase 1 Unc-51 Like Autophagy Activating Kinase 1 Unc-51-Like Kinase 1 |
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| Tree number(s): |
D08.811.913.696.620.682.700.108 D12.776.094.438 D12.776.476.563.108 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071189 | ||||||
| Scope note: | A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Previous Indexing: |
Protein-Serine-Threonine Kinases (1998-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56509 | ||||||
| Unique ID: | D000071189 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/02/25 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Autophagy-Related Protein-1 Homolog
- Preferred
| Concept UI |
M000613481 |
| Scope note | A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates. |
| Preferred term | Autophagy-Related Protein-1 Homolog |
| Entry term(s) |
Autophagy Related Protein 1 Homolog Serine Threonine Protein Kinase ULK1 Serine-Threonine Protein Kinase ULK1 ULK1 Protein Unc 51 Like Autophagy Activating Kinase 1 Unc 51 Like Kinase 1 Unc-51 Like Autophagy Activating Kinase 1 Unc-51-Like Kinase 1 |
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