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Descriptor English: Autophagy-Related Protein-1 Homolog
Descriptor Spanish: Homólogo de la Proteína 1 Relacionada con la Autofagia
Descriptor Portuguese: Proteína Homóloga à Proteína-1 Relacionada à Autofagia
Descriptor French: Homologue de la protéine-1 associée à l'autophagie
Entry term(s): Autophagy Related Protein 1 Homolog
Serine Threonine Protein Kinase ULK1
Serine-Threonine Protein Kinase ULK1
ULK1 Protein
Unc 51 Like Autophagy Activating Kinase 1
Unc 51 Like Kinase 1
Unc-51 Like Autophagy Activating Kinase 1
Unc-51-Like Kinase 1
Tree number(s): D08.811.913.696.620.682.700.108
D12.644.360.081
D12.776.094.438
D12.776.476.078
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071189
Scope note: A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.1
Previous Indexing: Protein-Serine-Threonine Kinases (1998-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56509
Unique ID: D000071189
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/25
Autophagy-Related Protein-1 Homolog - Preferred
Concept UI M000613481
Scope note A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.
Preferred term Autophagy-Related Protein-1 Homolog
Entry term(s) Autophagy Related Protein 1 Homolog
Serine Threonine Protein Kinase ULK1
Serine-Threonine Protein Kinase ULK1
ULK1 Protein
Unc 51 Like Autophagy Activating Kinase 1
Unc 51 Like Kinase 1
Unc-51 Like Autophagy Activating Kinase 1
Unc-51-Like Kinase 1



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