| Descriptor English: | Sequestosome-1 Protein | ||||||
| Descriptor Spanish: |
Proteína Sequestosoma-1
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| Descriptor Portuguese: | Proteína Sequestossoma-1 | ||||||
| Descriptor French: | Séquestosome-1 | ||||||
| Entry term(s): |
EBI3 Associated Protein of 60 KDa EBI3-Associated Protein of 60 KDa EBIAP Protein Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda Sequestosome 1 Protein Ubiquitin Binding Protein p62 Ubiquitin-Binding Protein p62 |
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| Tree number(s): |
D12.644.360.024.329 D12.776.094.750 D12.776.157.057.160 D12.776.476.024.422 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071456 | ||||||
| Scope note: | A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Adaptor Proteins, Signal Transducing (1996-2016) Heat-Shock Proteins (1996-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56538 | ||||||
| Unique ID: | D000071456 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/04/15 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Sequestosome-1 Protein
- Preferred
| Concept UI |
M000614776 |
| Scope note | A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS. |
| Preferred term | Sequestosome-1 Protein |
| Entry term(s) |
EBI3 Associated Protein of 60 KDa EBI3-Associated Protein of 60 KDa EBIAP Protein Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda Sequestosome 1 Protein Ubiquitin Binding Protein p62 Ubiquitin-Binding Protein p62 |
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