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Descriptor English: Sequestosome-1 Protein
Descriptor Spanish: Proteína Sequestosoma-1
Descriptor Portuguese: Proteína Sequestossoma-1
Descriptor French: Séquestosome-1
Entry term(s): EBI3 Associated Protein of 60 KDa
EBI3-Associated Protein of 60 KDa
EBIAP Protein
Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
Sequestosome 1 Protein
Ubiquitin Binding Protein p62
Ubiquitin-Binding Protein p62
Tree number(s): D12.644.360.024.329
D12.776.094.750
D12.776.157.057.160
D12.776.476.024.422
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071456
Scope note: A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Adaptor Proteins, Signal Transducing (1996-2016)
Heat-Shock Proteins (1996-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56538
Unique ID: D000071456
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15
Sequestosome-1 Protein - Preferred
Concept UI M000614776
Scope note A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
Preferred term Sequestosome-1 Protein
Entry term(s) EBI3 Associated Protein of 60 KDa
EBI3-Associated Protein of 60 KDa
EBIAP Protein
Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
Sequestosome 1 Protein
Ubiquitin Binding Protein p62
Ubiquitin-Binding Protein p62



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