| Descriptor in English: | Pyrin |
| Descriptor in Spanish: | Pirina |
| Descriptor in Portuguese: | Pirina |
| Descriptor in French: | Pyrine |
| Entry term(s): |
MEFV Protein Marenostrin Mediterranean Fever Protein TRIM20 Protein |
| Tree number(s): |
D12.776.220.909 D12.776.934.750 |
| Scope note: | A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER. |
| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
| History Note: | 2017 (1997) |
| See also the descriptors: |
Pyrin Domain
MeSH |
| DeCS UI: | 56595 |
| Descriptor UI: | D000071198 |
| Date Established: | 2017/01/01 |
| Date of Entry: | 2016/07/08 |
| Revision Date: | 2016/07/05 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Pyrin
- Preferred
| Concept UI |
M0281114 |
| Scope note | A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER. |
| Preferred term | Pyrin |
| Entry term(s) |
MEFV Protein Marenostrin Mediterranean Fever Protein TRIM20 Protein |
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