Search
Descriptor English: Tripartite Motif-Containing Protein 28
Descriptor Spanish: Proteína 28 que Contiene Motivos Tripartito
Descriptor proteína 28 que contiene motivos tripartito
Scope note: Proteína con motivo tripartito que consiste en un dedo RING N-terminal, dos DEDOS DE ZINC tipo B-box y un dominio PHD carboxiterminal. Actúa como represor transcripcional mediante la asociación con factores de transcripción del dominio de caja asociada a Kruppel (dominio KRAB) y tiene actividad E3-SUMO-ligasa hacia sí misma y también sumoíla el FACTOR 7 REGULADOR DEL INTERFERÓN, para reducir su actividad como activador transcripcional. También actúa como una ubiquitina-proteína-ligasa hacia la PROTEÍNA SUPRESORA DE TUMOR P53.
Descriptor Portuguese: Proteína 28 com Motivo Tripartido
Descriptor French: Protéine-28 à motif tripartite
Entry term(s): TRIM28 Protein
Tripartite Motif Containing Protein 28
Tree number(s): D08.811.464.938.750.782
D12.776.260.703.675
D12.776.930.780.911
D12.776.934.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076183
Scope note: A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.2.27
Previous Indexing: Repressor Proteins (2004-2017)
Public MeSH Note: 2018
History Note: 2018
Related: PHD Zinc Fingers MeSH
RING Finger Domains MeSH
DeCS ID: 57013
Unique ID: D000076183
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
Tripartite Motif-Containing Protein 28 - Preferred
Concept UI M000632418
Scope note A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.
Preferred term Tripartite Motif-Containing Protein 28
Entry term(s) TRIM28 Protein
Tripartite Motif Containing Protein 28



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey