Search
Descriptor English: Lysine Acetyltransferase 5
Descriptor Spanish: Lisina Acetiltransferasa 5
Descriptor lisina acetiltransferasa 5
Entry term(s) HTATIP
proteína KAT5 (TIP60)
proteína Tip60 interactiva con VIH 1 Tat
proteína Tip60 interactiva con VIH-1-Tat
Scope note: Subunidad catalítica del complejo histona acetil transferasa NuA4 que participa en la activación transcripcional de los genes por acetilación de las HISTONAS H4 y H2A del nucleosoma, alterando las interacciones nucleosoma-ADN y la interacción de las histonas modificadas con otros factores de transcripción activadores. Puede ejercer un control sobre cambios en la expresión de genes asociados a la inducción del crecimiento mediada por oncogenes y protooncogenes, la detención del crecimiento mediada por supresores tumorales, el ENVEJECIMIENTO CELULAR, la APOPTOSIS y la REPARACIÓN DEL ADN. Es poliubiquitinada y degradada durante la infección por el VIH-1 debido a su interacción con la PROTEÍNA TAT viral.
Descriptor Portuguese: Lisina Acetiltransferase 5
Descriptor French: Lysine acetyltransferase 5
Entry term(s): HIV 1 Tat Interactive Protein Tip60
HIV-1-Tat Interactive Protein Tip60
HTATIP
KAT5 (TIP60) Protein
Tree number(s): D08.811.913.050.134.415.500.062
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074443
Scope note: A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.1.48
Previous Indexing: Acetyltransferases (2002-2017)
Histone Acetyltransferases (2005-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57027
Unique ID: D000074443
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/05
Lysine Acetyltransferase 5 - Preferred
Concept UI M000626677
Scope note A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
Preferred term Lysine Acetyltransferase 5
Entry term(s) HIV 1 Tat Interactive Protein Tip60
HIV-1-Tat Interactive Protein Tip60
HTATIP
KAT5 (TIP60) Protein



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey