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Descriptor English: Nuclear Receptor Coactivator 3
Descriptor Spanish: Coactivador 3 de Receptor Nuclear
Descriptor coactivador 3 de receptores nucleares
Entry term(s) coactivador-3 de receptores nucleares
Scope note: Coactivador de receptores nucleares con especificidad para RECEPTORES DE ESTRÓGENOS y RECEPTORES DE PROGESTERONA. Tiene una actividad histona acetiltransferasa que puede desempeñar un papel en el ENSAMBLAJE Y DESENSAMBLAJE DE LA CROMATINA durante el proceso de transcripción inducida por receptores nucleares. El coactivador se ha encontrado en concentraciones elevadas en ciertas NEOPLASIAS HORMONO-DEPENDIENTES como el CÁNCER DE MAMA. 
Descriptor Portuguese: Coativador 3 de Receptor Nuclear
Descriptor French: Coactivateur-3 de récepteur nucléaire
Entry term(s): Amplified in Breast Cancer 1 Protein
Amplified in Breast Cancer-1 Protein
Nuclear Receptor Coactivator-3
Receptor Associated Coactivator 3
Receptor-Associated Coactivator 3
Steroid Receptor Coactivator 3
Thyroid Hormone Receptor Activator Molecule 1
Tree number(s): D08.811.913.050.134.415.500.150
D12.644.360.024.314.300
D12.776.157.057.080.300
D12.776.476.024.394.300
D12.776.660.675.300
D12.776.930.617.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D056921
Scope note: A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.1.48
Public MeSH Note: 2010; NUCLEAR RECEPTOR COACTIVATOR 3 was indexed under TRANSACTIVATORS and HISTONE ACETYLTRANSFERASES 1997-2009; THYROID HORMONE RECEPTOR ACTIVATOR MOLECULE 1 was indexed under TRANSCRIPTION FACTORS 2000-2009
History Note: 2010(1997)
DeCS ID: 53611
Unique ID: D056921
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/03/30
Nuclear Receptor Coactivator 3 - Preferred
Concept UI M0533386
Scope note A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.
Preferred term Nuclear Receptor Coactivator 3
Entry term(s) Amplified in Breast Cancer 1 Protein
Amplified in Breast Cancer-1 Protein
Nuclear Receptor Coactivator-3
Receptor Associated Coactivator 3
Receptor-Associated Coactivator 3
Steroid Receptor Coactivator 3
Thyroid Hormone Receptor Activator Molecule 1



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