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Descriptor English: p300-CBP Transcription Factors
Descriptor Spanish: Factores de Transcripción p300-CBP
Descriptor factores de transcripción p300-CBP
Scope note: Familia de histona acetiltransferasas relacionada estructuralmente con la PROTEÍNA DE UNIÓN A CREB y con la PROTEÍNA P300 ASOCIADA A E1A. Funcionan como coactivadores transcripcionales formando puentes entre los FACTORES DE TRANSCRIPCIÓN de unión al ADN y la maquinaria de transcripción basal. Modifican también los factores de transcripción y la CROMATINA mediante ACETILACIÓN.
Descriptor Portuguese: Fatores de Transcrição de p300-CBP
Descriptor French: Facteurs de transcription CBP-p300
Entry term(s): Coactivator, p300-CBP
Transcription Factors, p300-CBP
p300 CBP Coactivator
p300 CBP Protein
p300 CBP Transcription Factors
p300-CBP Coactivator
p300-CBP Protein
Tree number(s): D08.811.913.050.134.415.500.575
D12.776.930.680
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050880
Scope note: A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.1.48
Public MeSH Note: 2006; P300/CBP PROTEINS was indexed under NUCLEAR PROTEINS & TRANS-ACTIVATORS 1999-2005
History Note: 2006(1994)
DeCS ID: 50671
Unique ID: D050880
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/12/02
p300-CBP Transcription Factors - Preferred
Concept UI M0232680
Scope note A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.
Preferred term p300-CBP Transcription Factors
Entry term(s) Coactivator, p300-CBP
Transcription Factors, p300-CBP
p300 CBP Coactivator
p300 CBP Protein
p300 CBP Transcription Factors
p300-CBP Coactivator
p300-CBP Protein



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