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Descriptor English: WW Domains
Descriptor Spanish: Dominios WW
Descriptor dominios WW
Entry term(s) dominio WW
Scope note: Dominio proteínico de unos 40 aminoácidos que se encuentra en diversas proteínas no relacionadas y se puede repetir hasta cuatro veces en algunas proteínas. Se caracteriza por dos residuos de TRIPTÓFANO (WW) con una separación de unos 20 aminoácidos y se pliega en una LÁMINA BETA estable de tres filamentos. Se une a DOMINIOS PROTEICOS RICOS EN PROLINA y dominios proteicos que contienen FOSFOSERINA o FOSFOTREONINA presentes en numerosas proteínas transductoras de señal y del citoesqueleto, como la DISTROFINA.
Descriptor Portuguese: Domínios WW
Descriptor French: Domaines WW
Entry term(s): Domain, WW
Domains, WW
WW Domain
Tree number(s): G02.111.570.820.709.275.750.500.937
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074585
Scope note: An approximately 40 amino acid protein domain that occurs in a variety of unrelated proteins and may be repeated up to four times in some proteins. It is characterized by two TRYPTOPHAN residues (WW) about 20 amino acids apart and folds into a stable triple-stranded BETA-SHEET. It binds PROLINE-RICH PROTEIN DOMAINS and PHOSPHOSERINE or PHOSPHOTHREONINE-containing protein domains that occur in many signal-transducing and cytoskeletal proteins such as DYSTROPHIN.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Amino Acid Sequence (1996-2017)
Protein Structure, Tertiary (1999-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57257
Unique ID: D000074585
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2019/07/05
WW Domains - Preferred
Concept UI M000627070
Scope note An approximately 40 amino acid protein domain that occurs in a variety of unrelated proteins and may be repeated up to four times in some proteins. It is characterized by two TRYPTOPHAN residues (WW) about 20 amino acids apart and folds into a stable triple-stranded BETA-SHEET. It binds PROLINE-RICH PROTEIN DOMAINS and PHOSPHOSERINE or PHOSPHOTHREONINE-containing protein domains that occur in many signal-transducing and cytoskeletal proteins such as DYSTROPHIN.
Preferred term WW Domains
Entry term(s) Domain, WW
Domains, WW
WW Domain



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