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Descriptor English: Orlistat
Descriptor Spanish: Orlistat
Descriptor Portuguese: Orlistate
Descriptor French: Orlistat
Entry term(s): 1-((3-Hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate
Alli
Ro 18 0647
Ro-18-0647
THLP
Tetrahydrolipastatin
Tetrahydrolipstatin
Xenical
Tree number(s): D02.540.529
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077403
Scope note: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Enzyme Inhibitors
Anti-Obesity Agents
Lipid Regulating Agents
Registry Number: 95M8R751W8
CAS Type 1 Name: L-Leucine, N-formyl-, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester, (2S-(2alpha(R*),3beta))-
Public MeSH Note: 2019; ORLISTAT was indexed under LACTONES 1988-2018
History Note: 2019 (1988)
DeCS ID: 57631
Unique ID: D000077403
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/27
Orlistat - Preferred
Concept UI M0155332
Scope note A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.
Preferred term Orlistat
Entry term(s) THLP
Tetrahydrolipastatin
Tetrahydrolipstatin
Ro-18-0647 - Narrower
Concept UI M000640702
Preferred term Ro-18-0647
Entry term(s) Ro 18 0647
Alli - Narrower
Concept UI M0508612
Preferred term Alli
1-((3-Hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate - Related but not broader or narrower
Concept UI M000640701
Preferred term 1-((3-Hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate
Xenical - Narrower
Concept UI M0391326
Preferred term Xenical



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