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Descriptor English: Zearalenone
Descriptor Spanish: Zearalenona
Descriptor Portuguese: Zearalenona
Descriptor French: Zéaralénone
Entry term(s): F 2 Toxin
F-2 Toxin
F2 Toxin
Toxin, F-2
Toxin, F2
Tree number(s): D02.455.426.559.389.657.852.900
D02.540.950
D23.946.587.989
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015025
Scope note: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.
Annotation: a mycotoxin & non-steroidal estrogen; do not confuse with zearalanone (index under ZEARALENONE /analogs)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Estrogens, Non-Steroidal
Registry Number: 5W827M159J
CAS Type 1 Name: 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,5,6,9,10-hexahydro-14,16-dihydroxy-3-methyl-, (S-(E))-
Previous Indexing: Lactones (1966-1974)
Resorcinols (1966-1974)
Public MeSH Note: 91; was see under RESORCINOLS 1975-90
History Note: 91(75); was see under RESORCINOLS 1975-90
DeCS ID: 15421
Unique ID: D015025
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2013/07/08
Zearalenone - Preferred
Concept UI M0023120
Scope note (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.
Preferred term Zearalenone
Entry term(s) F 2 Toxin
F-2 Toxin
F2 Toxin
Toxin, F-2
Toxin, F2



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