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Qualifier English: 4-Butyrolactone
Qualifier Spanish: 4-Butirolactona
Qualifier Portuguese: 4-Butirolactona
Qualifier French: 4-Butyrolactone
Entry term(s): 1,4 Butanolide
1,4-Butanolide
4 Butyrolactone
4 Hydroxybutyric Acid Lactone
4-Hydroxybutyric Acid Lactone
Dihydro-2(3H)-furanone
Furanone, tetrahydro 2
Furanone, tetrahydro-2-
Lactone, 4-Hydroxybutyric Acid
gamma Butyrolactone
gamma-Butyrolactone
Tree number(s): D02.540.150
D03.383.312.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015107
Scope note: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Solvents
Registry Number: OL659KIY4X
CAS Type 1 Name: 2(3H)-Furanone, dihydro-
Previous Indexing: Furans (1969-1975)
Lactones (1969-1975)
Public MeSH Note: 91; was see under FURANS 1977-90; was GAMMA BUTYROLACTONE see under FURANS 1976
Online Note: use 4-BUTYROLACTONE to search GAMMA BUTYROLACTONE 1976
History Note: 91(77); was see under FURANS 1977-90; was GAMMA BUTYROLACTONE see under FURANS 1976
DeCS ID: 2122
Unique ID: D015107
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1975/07/23
Revision Date: 2016/05/27
4-Butyrolactone - Preferred
Concept UI M0023238
Scope note One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
Preferred term 4-Butyrolactone
Entry term(s) 1,4 Butanolide
1,4-Butanolide
4 Butyrolactone
4 Hydroxybutyric Acid Lactone
4-Hydroxybutyric Acid Lactone
Dihydro-2(3H)-furanone
Furanone, tetrahydro 2
Furanone, tetrahydro-2-
Lactone, 4-Hydroxybutyric Acid
gamma Butyrolactone
gamma-Butyrolactone



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