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Descriptor English:

Molindone

Descriptor Spanish:

Molindona

Spanish from Spain

Descriptor

molindona

Scope note:

Derivado indólico eficaz en la esquizofrenia y otras psicosis y, posiblemente, útil en el tratamiento del tipo agresivo de trastornos de la conducta sub-sociales. La molindona tiene mucha menos afinidad para los receptores D2 que la mayoría de los agentes antipsicóticos y tiene relativamente baja afinidad para los receptores D1. Su afinidad por los receptores colinérgicos y alfa-adrenérgicos es baja o moderada. Algunos datos electrofisiológicos de animales indican que la molindona tiene ciertas características que la asemejan a la CLOZAPINA. (de AMA Drug Evaluations Annual, 1994, p283)

Descriptor Portuguese:

Molindona

Descriptor French:

Molindone

Tree number(s):

D03.633.100.473.629

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D008972

Scope note:

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antipsychotic Agents

Registry Number:

RT3Y3QMF8N

CAS Type 1 Name:

4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-

DeCS ID:

9160

Unique ID:

D008972

Documents indexed in the Virtual Health Library (VHL):

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