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Descriptor English: Panobinostat
Descriptor Spanish: Panobinostat
Descriptor panobinostat
Entry term(s) Farydak
LBH 589
LBH589
NVP LBH589
NVP-LBH589
Scope note: Derivado del ácido hidroxámico y de indol que actúa como inhibidor de las HISTONA DESACETILASAS. Se usa como antineoplásico en combinación con BORTEZOMIB y DEXAMETASONA para el tratamiento del MIELOMA MÚLTIPLE.
Descriptor Portuguese: Panobinostat
Descriptor French: Panobinostat
Entry term(s): Farydak
LBH 589
LBH589
NVP LBH589
NVP-LBH589
Tree number(s): D02.092.570.394.535
D02.241.511.372.535
D03.633.100.473.746
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077767
Scope note: An indole and hydroxamic acid derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used as an antineoplastic agent in combination with BORTEZOMIB and DEXAMETHASONE for the treatment of MULTIPLE MYELOMA.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Histone Deacetylase Inhibitors
Registry Number: 9647FM7Y3Z
CAS Type 1 Name: 2-Propenamide, N-hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino) methyl)phenyl)-, (2E)-
Public MeSH Note: 2019; PANOBINOSTAT was indexed under HYDROXAMIC ACIDS and INDOLES 2005-2018
History Note: 2019 (2005)
DeCS ID: 57746
Unique ID: D000077767
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/05/21
Panobinostat - Preferred
Concept UI M0540392
Scope note An indole and hydroxamic acid derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used as an antineoplastic agent in combination with BORTEZOMIB and DEXAMETHASONE for the treatment of MULTIPLE MYELOMA.
Preferred term Panobinostat
LBH589 - Narrower
Concept UI M0481330
Preferred term LBH589
Entry term(s) LBH 589
NVP LBH589
NVP-LBH589
Farydak - Narrower
Concept UI M000602770
Preferred term Farydak



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