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Descriptor English: Duocarmycins
Descriptor Spanish: Duocarmicinas
Descriptor Portuguese: Duocarmicinas
Descriptor French: Without translation
Entry term(s): Duocarmycin
Tree number(s): D03.383.129.578.275
D03.633.100.473.278
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000080890
Scope note: A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antineoplastic
Antineoplastic Agents, Alkylating
Previous Indexing: Indoles (1988-2019)
Pyrroles (1988-2019)
Public MeSH Note: 2020
History Note: 2020
DeCS ID: 59086
Unique ID: D000080890
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/05/17
Duocarmycins - Preferred
Concept UI M000648583
Scope note A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity.
Preferred term Duocarmycins
Entry term(s) Duocarmycin



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