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Descriptor in English: Molindone
Descriptor in Spanish: Molindona
Descriptor in Portuguese: Molindona
Descriptor in French: Molindone
Entry term(s): Hydrochloride, Molindone
Moban
Molindone Hydrochloride
Molindone Monohydrochloride
Monohydrochloride, Molindone
Tree number(s): D03.633.100.473.629
Scope note: An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 91(72); was see under INDOLES 1972-90
DeCS UI: 9160
Descriptor UI: D008972
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Molindone - Preferred
Concept UI M0013989
Scope note An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)
Preferred term Molindone
Moban - Narrower
Concept UI M0013990
Preferred term Moban
Molindone Hydrochloride - Narrower
Concept UI M0330042
Preferred term Molindone Hydrochloride
Entry term(s) Hydrochloride, Molindone
Molindone Monohydrochloride
Monohydrochloride, Molindone



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