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Descriptor English: Muscimol
Descriptor Spanish: Muscimol
Descriptor muscimol
Entry term(s) agarin
panterina
Scope note: Isoxazol neurotóxico aislado de la Amanita muscaria y A. phalloides, que también se obtiene mediante descarboxilación del ÁCIDO IBOTÉNICO. Es un potente agonista de los receptores GABA-A y se utiliza principalmente como herramienta experimental en estudios sobre animales y tejidos.
Descriptor Portuguese: Muscimol
Descriptor French: Muscimol
Entry term(s): Agarin
Pantherine
Tree number(s): D03.383.129.462.470
D23.946.587.587
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009118
Scope note: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: GABA-A Receptor Agonists
Registry Number: 2763-96-4
CAS Type 1 Name: 3(2H)-Isoxazolone, 5-(aminomethyl)-
Previous Indexing: Mycotoxins (1967-1978)
Oxazoles (1966-1978)
Toxins (1966)
Public MeSH Note: 86; was see under OXAZOLES 1979-85
History Note: 86(79); was see under OXAZOLES 1979-85
Related: Receptors, GABA-A MeSH
DeCS ID: 9308
Unique ID: D009118
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1978/05/03
Revision Date: 2016/05/31
Muscimol - Preferred
Concept UI M0014231
Scope note A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
Preferred term Muscimol
Entry term(s) Agarin
Pantherine



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