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Descriptor English: Procollagen N-Endopeptidase
Descriptor Spanish: Procolágeno N-Endopeptidasa
Descriptor procolágeno N-endopeptidasa
Entry term(s) procolágeno peptidasa
Scope note: Endopeptidasa extracelular que escinde un bloque de péptidos de la región amino terminal, no helicoidal, de la molécula de procolágeno, con la formación de colágeno. La ausencia o deficiencia de la enzima provoca el almacenamiento de procolágeno, provocando la dermatosparaxis, un trastorno hereditario del tejido conjuntivo. EC 3.4.24.14.
Descriptor Portuguese: Pró-Colágeno N-Endopeptidase
Descriptor French: Procollagen peptidase
Entry term(s): Procollagen N Endopeptidase
Procollagen N Proteinase
Procollagen N-Proteinase
Procollagen Peptidase
Tree number(s): D08.811.277.656.300.480.664
D08.811.277.656.675.374.664
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011348
Scope note: An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.24.14
Previous Indexing: Collagen (1966-1976)
Peptide Peptidohydrolases (1966-1976)
Protein Precursors (1973-1976)
Public MeSH Note: 97; was PROCOLLAGEN PEPTIDASE 1977-96 (see under PEPTIDE PEPTIDOHYDROLASES 1977-90)
History Note: 97; was PROCOLLAGEN PEPTIDASE 1977-96 (see under ENDOPEPTIDASES 1977-90)
DeCS ID: 11784
Unique ID: D011348
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1976/04/27
Revision Date: 2003/07/09
Procollagen N-Endopeptidase - Preferred
Concept UI M0017631
Scope note An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.
Preferred term Procollagen N-Endopeptidase
Entry term(s) Procollagen N Endopeptidase
Procollagen N Proteinase
Procollagen N-Proteinase
Procollagen Peptidase



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