| Descriptor English: | Pregnancy-Associated Plasma Protein-A | ||||||
| Descriptor Spanish: |
Proteína Plasmática A Asociada al Embarazo
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| Descriptor Portuguese: | Proteína Plasmática A Associada à Gravidez | ||||||
| Descriptor French: | Protéine A plasmatique associée à la grossesse | ||||||
| Entry term(s): |
IGFBP 4 Metalloproteinase IGFBP 4 Protease IGFBP-4 Metalloproteinase IGFBP-4 Protease IGFBP-4-Specific Proteinase Insulin Like Growth Factor Binding Protein 4 Protease Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease Insulin-Like-Growth Factor Binding Protein-4 Protease Metalloproteinase, IGFBP-4 PAPP alpha PAPP-A PAPP-alpha Pregnancy Associated Plasma Protein A Pregnancy Associated alpha Plasma Protein Pregnancy-Associated alpha-Plasma Protein Protease, IGFBP-4 |
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| Tree number(s): |
D08.811.277.656.300.480.632 D08.811.277.656.675.374.632 D12.776.780.700 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D011266 | ||||||
| Scope note: | A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.4.24.- | ||||||
| Previous Indexing: |
Alpha Globulins (1966-1979) Alpha Macroglobulins (1976-1979) Blood Proteins (1966-1979) Glycoproteins (1966-1979) Pregnancy (1966-1979) |
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| Public MeSH Note: | 2004; for PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN see PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN 1991-2003, see PREGNANCY PROTEINS 1980-1990 |
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| History Note: | 2004 (1996) |
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| Entry Version: | PREGN ASSOCIATED PLASMA PROTEIN A |
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| DeCS ID: | 11686 | ||||||
| Unique ID: | D011266 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1979/02/22 | ||||||
| Revision Date: | 2004/07/13 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Pregnancy-Associated Plasma Protein-A
- Preferred
| Concept UI |
M0017493 |
| Scope note | A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa. |
| Preferred term | Pregnancy-Associated Plasma Protein-A |
| Entry term(s) |
IGFBP 4 Metalloproteinase IGFBP 4 Protease IGFBP-4 Metalloproteinase IGFBP-4 Protease IGFBP-4-Specific Proteinase Insulin Like Growth Factor Binding Protein 4 Protease Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease Insulin-Like-Growth Factor Binding Protein-4 Protease Metalloproteinase, IGFBP-4 PAPP alpha PAPP-A PAPP-alpha Pregnancy Associated Plasma Protein A Pregnancy Associated alpha Plasma Protein Pregnancy-Associated alpha-Plasma Protein Protease, IGFBP-4 |
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