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Descriptor English: Quinine
Descriptor Spanish: Quinina
Descriptor quinina
Scope note: Alcaloide derivado de la corteza del árbol Cinchona. Es un fármaco antimalárico y constituye el ingrediente activo de los extractos de cinchona que se han utilizado para este propósito desde antes del 1633. La quinina es también un antipirético y analgésico suave y ha sido utilizado para estos propósitos en preparados contra el resfriado común. Otros usos de la quinina son: como agente amargante y odorizante y, en la actualidad, aún se utiliza en el tratamiento de la babesiosis. Además, la quinina es útil en algunas enfermedades musculares, especialmente calambres nocturnos de las piernas y miotonía congénita, debido a sus efectos directos sobre la membrana muscular y los canales de sodio. El mecanismo de sus efectos antimaláricos aún no se conocen bien.
Descriptor Portuguese: Quinina
Descriptor French: Quinine
Entry term(s): Chlorhydrate de quinine
Hydrogénosulfate de quinine
Sulfate de quinine
Tree number(s): D03.132.206.719
D03.605.687.762
D03.633.100.810.762
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011803
Scope note: An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Annotation: /biosyn permitted if by plant
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Antimalarials
Muscle Relaxants, Central
Analgesics, Non-Narcotic
Registry Number: A7V27PHC7A
CAS Type 1 Name: Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-
DeCS ID: 12240
Unique ID: D011803
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Quinine - Preferred
Concept UI M0018346
Preferred term Quinine
Hydrogénosulfate de quinine - Narrower
Concept UI M0018347
Preferred term Hydrogénosulfate de quinine
Chlorhydrate de quinine - Narrower
Concept UI M0018348
Preferred term Chlorhydrate de quinine
Sulfate de quinine - Narrower
Concept UI M0018349
Preferred term Sulfate de quinine



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