DeCS

Descriptor English:

DNA, Circular

Descriptor Spanish:

ADN Circular

Spanish from Spain

Descriptor	ADN circular
Entry term(s)	DNA circular
Scope note:	Cualquiera de las moléculas de ADN covalentemente cerradas que se encuentran en bacterias, muchos virus, mitocondrias, plástidos y plásmidos. También se han encontrado ADN pequeños, circulares y polidispersos en algunos organismos eucariotas, y se ha sugerido que tienen homología con el ADN cromosómico y la capacidad de insertarse en él y escindirse de él. Es un fragmento de ADN formado por un proceso de formación de un bucle y deleción, que contiene una región constante de la cadena pesada mu y la parte 3' de la región de cambio mu. El ADN circular es un producto normal de la reordenación entre segmentos génicos que codifican las regiones variables de las cadenas ligeras y pesadas de las inmunoglobulinas, así como el receptor de los linfocitos T. (Riger et al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)

Descriptor Portuguese:

DNA Circular

Descriptor French:

ADN circulaire

Entry term(s):

Circular DNA
Circular DNAs
DNAs, Circular

Tree number(s):

D13.444.308.283
G02.111.570.820.486.212
G05.360.580.156

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D004270

Scope note:

Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria, plastids, and plasmids. Small, polydisperse circular DNA's have also been observed in a number of eukaryotic organisms and are suggested to have homology with chromosomal DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is a fragment of DNA formed by a process of looping out and deletion, containing a constant region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA is a normal product of rearrangement among gene segments encoding the variable regions of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)

Annotation:

IM; /drug eff /ultrastruct permitted

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M0006682
Scope note	Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria, plastids, and plasmids. Small, polydisperse circular DNA's have also been observed in a number of eukaryotic organisms and are suggested to have homology with chromosomal DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is a fragment of DNA formed by a process of looping out and deletion, containing a constant region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA is a normal product of rearrangement among gene segments encoding the variable regions of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)
Preferred term	DNA, Circular
Entry term(s)	Circular DNA Circular DNAs DNAs, Circular

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