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Descriptor English: Protein Sorting Signals
Descriptor Spanish: Señales de Clasificación de Proteína
Descriptor Portuguese: Sinais Direcionadores de Proteínas
Descriptor French: Signaux de triage des protéines
Entry term(s): Leader Peptide
Leader Peptides
Leader Sequence, Peptide
Leader Sequences, Peptide
Leader Signal Peptide
Leader Signal Peptides
Peptide Leader Sequence
Peptide Leader Sequences
Peptide Signal Sequence
Peptide Signal Sequences
Peptide, Leader
Peptide, Leader Signal
Peptide, Signal
Peptides, Leader
Peptides, Leader Signal
Peptides, Signal
Protein Sorting Signal
Sequence, Peptide Leader
Sequence, Peptide Signal
Sequence, Signal
Sequences, Peptide Leader
Sequences, Peptide Signal
Sequences, Signal
Signal Peptide
Signal Peptide, Leader
Signal Peptides
Signal Peptides, Leader
Signal Sequence
Signal Sequence, Peptide
Signal Sequences
Signal Sequences, Peptide
Signal, Protein Sorting
Signals, Protein Sorting
Sorting Signal, Protein
Sorting Signals, Protein
Tree number(s): D12.644.770
G02.111.570.060.670
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D021382
Scope note: Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.
Annotation:
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
PH physiology
RE radiation effects
Public MeSH Note: 2001; see Signal Peptides 1986-2000
History Note: 2001(1986)
Related: Protein Transport MeSH
Signal Recognition Particle MeSH
DeCS ID: 19599
Unique ID: D021382
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2001/01/01
Date of Entry: 2000/07/06
Revision Date: 2008/07/08
Protein Sorting Signals - Preferred
Concept UI M0352619
Scope note Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.
Preferred term Protein Sorting Signals
Entry term(s) Protein Sorting Signal
Signal, Protein Sorting
Signals, Protein Sorting
Sorting Signal, Protein
Sorting Signals, Protein
Leader Signal Peptides - Narrower
Concept UI M0358903
Preferred term Leader Signal Peptides
Entry term(s) Leader Peptide
Leader Peptides
Leader Sequence, Peptide
Leader Sequences, Peptide
Leader Signal Peptide
Peptide Leader Sequence
Peptide Leader Sequences
Peptide, Leader
Peptide, Leader Signal
Peptides, Leader
Peptides, Leader Signal
Sequence, Peptide Leader
Sequences, Peptide Leader
Signal Peptide, Leader
Signal Peptides, Leader
Signal Peptides - Narrower
Concept UI M0019841
Scope note Highly hydrophobic amino acid sequences of proteins that must cross through membranes to arrive at their functioning cellular location (such as secreted and membrane proteins). They are 15 to 60 amino acids long and reside at the amino-terminus (leader signal peptides) or internally. By binding to signal recognition particles, these sequences direct nascent protein-ribosome complexes to a membrane where the protein is inserted during translation. Signal peptides direct translational uptake of the protein by various membranes -endoplamic reticulum, mitochondrial, chloroplast, peroxisomal, etc. Leader signal sequences on non-membrane proteins are ultimately removed by specific peptidases.
Preferred term Signal Peptides
Entry term(s) Peptide Signal Sequence
Peptide Signal Sequences
Peptide, Signal
Peptides, Signal
Sequence, Peptide Signal
Sequence, Signal
Sequences, Peptide Signal
Sequences, Signal
Signal Peptide
Signal Sequence
Signal Sequence, Peptide
Signal Sequences
Signal Sequences, Peptide



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