CHEMICALS AND DRUGS Amino Acids, Peptides, and Proteins [D12] Amino Acids, Peptides, and Proteins Peptides [D12.644] Peptides Amyloid beta-Peptides [D12.644.024] Amyloid beta-Peptides Antimicrobial Cationic Peptides [D12.644.050] Antimicrobial Cationic Peptides Antimicrobial Peptides [D12.644.066] Antimicrobial Peptides Aptamers, Peptide [D12.644.082] Aptamers, Peptide Cell-Penetrating Peptides [D12.644.098] Cell-Penetrating Peptides Charybdotoxin [D12.644.115] Charybdotoxin Cholecystokinin [D12.644.120] Cholecystokinin Cystine-Knot Miniproteins [D12.644.132] Cystine-Knot Miniproteins Diazepam Binding Inhibitor [D12.644.136] Diazepam Binding Inhibitor Disintegrins [D12.644.138] Disintegrins Distamycins [D12.644.140] Distamycins Edeine [D12.644.146] Edeine Erabutoxins [D12.644.173] Erabutoxins Exenatide [D12.644.187] Exenatide Fibrinopeptide A [D12.644.200] Fibrinopeptide A Fibrinopeptide B [D12.644.205] Fibrinopeptide B Glatiramer Acetate [D12.644.219] Glatiramer Acetate Glycopeptides [D12.644.233] Glycopeptides Intercellular Signaling Peptides and Proteins [D12.644.276] Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins [D12.644.360] Intracellular Signaling Peptides and Proteins Lipopeptides [D12.644.365] Lipopeptides Mating Factor [D12.644.368] Mating Factor Myocardial Depressant Factor [D12.644.370] Myocardial Depressant Factor Neuropeptides [D12.644.400] Neuropeptides Oligopeptides [D12.644.456] Oligopeptides Peptaibols [D12.644.504] Peptaibols Peptide Fragments [D12.644.541] Peptide Fragments Peptide Hormones [D12.644.548] Peptide Hormones Peptide Library [D12.644.555] Peptide Library Peptides, Cyclic [D12.644.641] Peptides, Cyclic Peptoids [D12.644.679] Peptoids Phosphopeptides [D12.644.717] Phosphopeptides Polygeline [D12.644.740] Polygeline Polyglutamic Acid [D12.644.748] Polyglutamic Acid Polylysine [D12.644.760] Polylysine Protein Sorting Signals [D12.644.770] Protein Sorting Signals Nuclear Export Signals [D12.644.770.600] Nuclear Export Signals Nuclear Localization Signals [D12.644.770.610] Nuclear Localization Signals Peroxisomal Targeting Signals [D12.644.770.805] Peroxisomal Targeting Signals Proteinase Inhibitory Proteins, Secretory [D12.644.822] Proteinase Inhibitory Proteins, Secretory Salivary Proteins and Peptides [D12.644.848] Salivary Proteins and Peptides Serpins [D12.644.861] Serpins Tissue Polypeptide Antigen [D12.644.875] Tissue Polypeptide Antigen Trefoil Factors [D12.644.937] Trefoil Factors PHENOMENA AND PROCESSES Chemical Phenomena [G02] Chemical Phenomena Biochemical Phenomena [G02.111] Biochemical Phenomena Molecular Structure [G02.111.570] Molecular Structure Amino Acid Sequence [G02.111.570.060] Amino Acid Sequence Exteins [G02.111.570.060.270] Exteins Histone Code [G02.111.570.060.360] Histone Code Immunoglobulin Variable Region [G02.111.570.060.425] Immunoglobulin Variable Region Inteins [G02.111.570.060.440] Inteins Peptide Library [G02.111.570.060.620] Peptide Library Protein Sorting Signals [G02.111.570.060.670] Protein Sorting Signals Nuclear Export Signals [G02.111.570.060.670.600] Nuclear Export Signals Nuclear Localization Signals [G02.111.570.060.670.610] Nuclear Localization Signals Peroxisomal Targeting Signals [G02.111.570.060.670.805] Peroxisomal Targeting Signals Repetitive Sequences, Amino Acid [G02.111.570.060.720] Repetitive Sequences, Amino Acid

Protein Sorting Signals - Preferred

Concept UI	M0352619
Scope note	Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.
Preferred term	Protein Sorting Signals
Entry term(s)	Protein Sorting Signal Signal, Protein Sorting Signals, Protein Sorting Sorting Signal, Protein Sorting Signals, Protein

Leader Signal Peptides - Narrower

Concept UI	M0358903
Preferred term	Leader Signal Peptides
Entry term(s)	Leader Peptide Leader Peptides Leader Sequence, Peptide Leader Sequences, Peptide Leader Signal Peptide Peptide Leader Sequence Peptide Leader Sequences Peptide, Leader Peptide, Leader Signal Peptides, Leader Peptides, Leader Signal Sequence, Peptide Leader Sequences, Peptide Leader Signal Peptide, Leader Signal Peptides, Leader

Signal Peptides - Narrower

Concept UI	M0019841
Scope note	Highly hydrophobic amino acid sequences of proteins that must cross through membranes to arrive at their functioning cellular location (such as secreted and membrane proteins). They are 15 to 60 amino acids long and reside at the amino-terminus (leader signal peptides) or internally. By binding to signal recognition particles, these sequences direct nascent protein-ribosome complexes to a membrane where the protein is inserted during translation. Signal peptides direct translational uptake of the protein by various membranes -endoplamic reticulum, mitochondrial, chloroplast, peroxisomal, etc. Leader signal sequences on non-membrane proteins are ultimately removed by specific peptidases.
Preferred term	Signal Peptides
Entry term(s)	Peptide Signal Sequence Peptide Signal Sequences Peptide, Signal Peptides, Signal Sequence, Peptide Signal Sequence, Signal Sequences, Peptide Signal Sequences, Signal Signal Peptide Signal Sequence Signal Sequence, Peptide Signal Sequences Signal Sequences, Peptide