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Descriptor English: Cathepsin B
Descriptor Spanish: Catepsina B
Descriptor catepsina B
Entry term(s) catepsina B1
Scope note: Cisteína proteinasa lisosómica con especificidad similar a la de la PAPAÍNA. Está presente en diversos tejidos y es importante en muchos procesos fisiológicos y patológicos. Se ha visto que la catepsina B está implicada en la DESMIELINIZACIÓN, el ENFISEMA, la ARTRITIS REUMATOIDE y la INVASIVIDAD DE NEOPLASIAS.
Descriptor Portuguese: Catepsina B
Descriptor French: Cathepsine B
Entry term(s): Cathepsin B Like Proteinase
Cathepsin B-Like Proteinase
Cathepsin B1
Proteinase, Cathepsin B-Like
Tree number(s): D08.811.277.656.224.125
D08.811.277.656.262.500.133
D08.811.277.656.300.200.133
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002401
Scope note: A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.22.1
Previous Indexing: Cathepsins (1966-1986)
Public MeSH Note: 87
History Note: 87
DeCS ID: 23222
Unique ID: D002401
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/16
Revision Date: 2009/07/06
Cathepsin B - Preferred
Concept UI M0003657
Scope note A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
Preferred term Cathepsin B
Entry term(s) Cathepsin B1
Cathepsin B-Like Proteinase - Related but not broader or narrower
Concept UI M0003659
Preferred term Cathepsin B-Like Proteinase
Entry term(s) Cathepsin B Like Proteinase
Proteinase, Cathepsin B-Like



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