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Descriptor English: Separase
Descriptor Spanish: Separasa
Descriptor separasa
Scope note: La separasa es una proteasa de cisteína parecida a la caspasa, que juega un importante papel en el desencadenamiento de la ANAFASE mediante la escisión de la subunidad SCC1/RAD21 del complejo cohesina. La cohesina se une a las CROMÁTIDAS hermanas durante la METAFASE y su división se traduce en la segregación cromosómica.
Descriptor Portuguese: Separase
Descriptor French: Separase
Tree number(s): D08.811.277.656.262.500.792
D08.811.277.656.300.200.792
D12.776.167.552
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064247
Scope note: Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.22.49
Previous Indexing: Cell Cycle Proteins (1999-2013)
Endopeptidases (1999-2013)
Public MeSH Note: 2014; was indexed under ENDOPEPTIDASES and CELL CYCLE PROTEINS 1999-2013
History Note: 2014
DeCS ID: 55268
Unique ID: D064247
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Separase - Preferred
Concept UI M0580540
Scope note Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
Preferred term Separase



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