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Descriptor English: Tumor Necrosis Factor-alpha
Descriptor Spanish: Factor de Necrosis Tumoral alfa
Descriptor Portuguese: Fator de Necrose Tumoral alfa
Descriptor French: Facteur de nécrose tumorale alpha
Entry term(s): Cachectin
Cachectin Tumor Necrosis Factor
Cachectin-Tumor Necrosis Factor
TNF Superfamily, Member 2
TNF-alpha
TNFalpha
Tumor Necrosis Factor
Tumor Necrosis Factor Ligand Superfamily Member 2
Tumor Necrosis Factor alpha
Tree number(s): D12.644.276.374.500.800
D12.644.276.374.750.626
D12.776.124.900
D12.776.395.930
D12.776.467.374.500.800
D12.776.467.374.750.626
D23.529.374.500.800
D23.529.374.750.626
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014409
Scope note: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Annotation:
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Endotoxins (1975-1987)
Glycoproteins (1975-1987)
Necrosis (1975-1987)
Public MeSH Note: 2005; see TUMOR NECROSIS FACTOR 1988-2005
History Note: 2005(1988)
Related: Adalimumab MeSH
Certolizumab Pegol MeSH
Infliximab MeSH
DeCS ID: 29591
Unique ID: D014409
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1988/01/01
Date of Entry: 1987/05/08
Revision Date: 2017/06/20
Tumor Necrosis Factor-alpha - Preferred
Concept UI M0022150
Scope note Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Preferred term Tumor Necrosis Factor-alpha
Entry term(s) Cachectin
Cachectin Tumor Necrosis Factor
Cachectin-Tumor Necrosis Factor
TNF Superfamily, Member 2
TNF-alpha
TNFalpha
Tumor Necrosis Factor
Tumor Necrosis Factor Ligand Superfamily Member 2
Tumor Necrosis Factor alpha



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