| Descriptor English: | Tumor Necrosis Factor-alpha | ||||||
| Descriptor Spanish: |
Factor de Necrosis Tumoral alfa
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| Descriptor Portuguese: | Fator de Necrose Tumoral alfa | ||||||
| Descriptor French: | Facteur de nécrose tumorale alpha | ||||||
| Entry term(s): |
Cachectin Cachectin Tumor Necrosis Factor Cachectin-Tumor Necrosis Factor TNF Superfamily, Member 2 TNF-alpha TNFalpha Tumor Necrosis Factor Tumor Necrosis Factor Ligand Superfamily Member 2 Tumor Necrosis Factor alpha |
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| Tree number(s): |
D12.644.276.374.500.800 D12.644.276.374.750.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D23.529.374.500.800 D23.529.374.750.626 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D014409 | ||||||
| Scope note: | Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Endotoxins (1975-1987) Glycoproteins (1975-1987) Necrosis (1975-1987) |
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| Public MeSH Note: | 2005; see TUMOR NECROSIS FACTOR 1988-2005 |
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| History Note: | 2005(1988) |
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| Related: |
Adalimumab
MeSH Certolizumab Pegol MeSH Infliximab MeSH | ||||||
| DeCS ID: | 29591 | ||||||
| Unique ID: | D014409 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1988/01/01 | ||||||
| Date of Entry: | 1987/05/08 | ||||||
| Revision Date: | 2017/06/20 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Tumor Necrosis Factor-alpha
- Preferred
| Concept UI |
M0022150 |
| Scope note | Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. |
| Preferred term | Tumor Necrosis Factor-alpha |
| Entry term(s) |
Cachectin Cachectin Tumor Necrosis Factor Cachectin-Tumor Necrosis Factor TNF Superfamily, Member 2 TNF-alpha TNFalpha Tumor Necrosis Factor Tumor Necrosis Factor Ligand Superfamily Member 2 Tumor Necrosis Factor alpha |
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