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Descriptor English: CD4 Immunoadhesins
Descriptor Spanish: Inmunoadhesinas CD4
Descriptor inmunodhesinas CD4
Entry term(s) CD4-IgG
Scope note: Moléculas quiméricas resultantes de la fusión de CD4 soluble recombinante con la porción Fc de las inmunoglobulinas. Tienen un empleo potencial en el tratamiento del SIDA ya que poseen propiedades de unión a gp120 y de bloqueo del VIH de rCD4 así como una gran semivida plasmática y funcioones de unión al receptor Fc de la inmunoglobulina.
Descriptor Portuguese: Imunoadesinas CD4
Descriptor French: Immunoadhésines CD4
Entry term(s): CD4 IgG
CD4-IgG
Immunoadhesins, CD4
Tree number(s): D09.400.430.890.200.230
D12.644.541.500.697.249
D12.776.124.486.485.538.500.249
D12.776.124.486.485.680.697.249
D12.776.124.790.651.538.500.249
D12.776.124.790.651.680.660.249
D12.776.377.715.548.538.500.249
D12.776.377.715.548.680.660.249
D12.776.395.550.200.230
D12.776.543.550.200.230
D12.776.828.300.200
D23.050.301.350.230
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016860
Scope note: Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and Fc receptor-binding functions of immunoglobulin.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Antigens, CD (1990-1991)
Antigens, Differentiation, T-Lymphocyte (1989)
IgG (1989-1991)
Public MeSH Note: 92; CD4 IMMUNOADHESIN (NM) was indexed under IGG & ANTIGENS, CD & ANTIBODIES, ANTI-IDIOTYPIC 1990-91 and under ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1989.
Online Note: use CD4 IMMUNOADHESINS (NM) to search CD4 IMMUNOADHESIN (NM) 1989-91
History Note: 92; was CD4 IMMUNOADHESIN (NM) 1989-91
DeCS ID: 30208
Unique ID: D016860
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/07/12
Revision Date: 2010/06/25
CD4 Immunoadhesins - Preferred
Concept UI M0025662
Scope note Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and Fc receptor-binding functions of immunoglobulin.
Preferred term CD4 Immunoadhesins
Entry term(s) Immunoadhesins, CD4
CD4-IgG - Narrower
Concept UI M0025663
Preferred term CD4-IgG
Entry term(s) CD4 IgG



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