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Descriptor English: Alefacept
Descriptor Spanish: Alefacept
Descriptor alefacept
Entry term(s) Amevive
proteína de fusión LFA 3/IgG1
proteína de fusión LFA-3 IgG(1)
proteína de fusión LFA-3/IgG1
Scope note: Proteína de fusión humana recombinante del antígeno LFA-3 y la inmunoglobulina IgG1 que se une a ANTÍGENOS CD2 en los LINFOCITOS T de memoria, impidiendo su activación y proliferación. Se usa en el tratamiento de la PSORIASIS en placas crónica de moderada a intensa.
Descriptor Portuguese: Alefacept
Descriptor French: Alefacept
Entry term(s): Amevive
LFA 3 IgG1 Fusion Protein
LFA-3 IgG(1) Fusion Protein
LFA-3 IgG1 Fusion Protein
Tree number(s): D09.400.430.890.034.500
D12.776.124.486.485.114.619.393.131
D12.776.124.790.651.114.619.393.131
D12.776.377.715.548.114.619.393.131
D12.776.395.550.034.500
D12.776.543.550.158.500
D12.776.828.300.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077944
Scope note: A recombinant human fusion protein of LFA-3 antigen and immunoglobulin IGG1 that binds to CD2 ANTIGENS on memory T-LYMPHOCYTES, preventing their activation and proliferation. It is used in the management of moderate to severe chronic plaque PSORIASIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Dermatologic Agents
Immunologic Factors
Registry Number: ELK3V90G6C
Public MeSH Note: 2019; ALEFACEPT was indexed under RECOMBINANT FUSION PROTEINS 2000-2018
History Note: 2019 (2000)
DeCS ID: 57775
Unique ID: D000077944
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/05/21
Alefacept - Preferred
Concept UI M0374901
Scope note A recombinant human fusion protein of LFA-3 antigen and immunoglobulin IGG1 that binds to CD2 ANTIGENS on memory T-LYMPHOCYTES, preventing their activation and proliferation. It is used in the management of moderate to severe chronic plaque PSORIASIS.
Preferred term Alefacept
Entry term(s) LFA 3 IgG1 Fusion Protein
LFA-3 IgG(1) Fusion Protein
LFA-3 IgG1 Fusion Protein
Amevive - Narrower
Concept UI M0446620
Preferred term Amevive



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