| Descriptor English: | BRCA1 Protein | ||||||
| Descriptor Spanish: |
Proteína BRCA1
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| Descriptor Portuguese: | Proteína BRCA1 | ||||||
| Descriptor French: | Protéine BRCA1 | ||||||
| Entry term(s): |
BRCA1 Gene Product Breast Cancer 1 Gene Product Breast Cancer 1 Protein Breast Cancer Type 1 Susceptibility Protein Ring Finger Protein 53 |
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| Tree number(s): |
D12.776.313.125 D12.776.624.776.100 D12.776.660.100 D12.776.744.100 D12.776.930.137 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019313 | ||||||
| Scope note: | The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91) |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Neoplasm Proteins (1994-1996) Transcription Factors (1994-1996) |
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| Public MeSH Note: | 97; BCRA1 PROTEIN was indexed under NEOPLASM PROTEINS & TRANSCRIPTION FACTORS 1994-96 |
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| Online Note: | use BRCA1 PROTEIN (NM) to search BRCA1 PROTEIN 1994-96 |
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| History Note: | 97; was BRCA1 PROTEIN (NM) 1994-96 |
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| Related: |
Genes, BRCA1
MeSH Hereditary Breast and Ovarian Cancer Syndrome MeSH | ||||||
| DeCS ID: | 33059 | ||||||
| Unique ID: | D019313 | ||||||
| NLM Classification: | WP 870 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1997/01/01 | ||||||
| Date of Entry: | 1996/06/10 | ||||||
| Revision Date: | 2015/11/23 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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BRCA1 Protein
- Preferred
| Concept UI |
M0028758 |
| Scope note | The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91) |
| Preferred term | BRCA1 Protein |
| Entry term(s) |
BRCA1 Gene Product Breast Cancer 1 Gene Product Breast Cancer 1 Protein Breast Cancer Type 1 Susceptibility Protein Ring Finger Protein 53 |
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