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Descriptor English: BRCA1 Protein
Descriptor Spanish: Proteína BRCA1
Descriptor proteína BRCA1
Entry term(s) producto del gen BRCA1
producto del gen de cáncer de mama 1
proteína RING finger 53
proteína de susceptibilidad al cáncer de mama tipo 1
Scope note: Fosfoproteína codificada por el gen BRCA1 (GENES BRCA1). Contiene un DOMINIO RING FINGER N-terminal y es una subunidad reguladora de la PROTEÍNA FOSFATASA 1. En las células normales la proteína BRCA1 se localiza en el núcleo, mientras que en la mayoría de las líneas celulares de cáncer de mama y en los derrames pleurales malignos que se producen en las pacientes con cáncer de mama, se localiza fundamentalmente en el citoplasma. (Traducción libre del original: Science 1995;270(5237):713,789-91)
Descriptor Portuguese: Proteína BRCA1
Descriptor French: Protéine BRCA1
Entry term(s): BRCA1 Gene Product
Breast Cancer 1 Gene Product
Breast Cancer 1 Protein
Breast Cancer Type 1 Susceptibility Protein
Ring Finger Protein 53
Tree number(s): D12.776.313.125
D12.776.624.776.100
D12.776.660.100
D12.776.744.100
D12.776.930.137
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019313
Scope note: The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Neoplasm Proteins (1994-1996)
Transcription Factors (1994-1996)
Public MeSH Note: 97; BCRA1 PROTEIN was indexed under NEOPLASM PROTEINS & TRANSCRIPTION FACTORS 1994-96
Online Note: use BRCA1 PROTEIN (NM) to search BRCA1 PROTEIN 1994-96
History Note: 97; was BRCA1 PROTEIN (NM) 1994-96
Related: Genes, BRCA1 MeSH
Hereditary Breast and Ovarian Cancer Syndrome MeSH
DeCS ID: 33059
Unique ID: D019313
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2015/11/23
BRCA1 Protein - Preferred
Concept UI M0028758
Scope note The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
Preferred term BRCA1 Protein
Entry term(s) BRCA1 Gene Product
Breast Cancer 1 Gene Product
Breast Cancer 1 Protein
Breast Cancer Type 1 Susceptibility Protein
Ring Finger Protein 53



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