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Descriptor English: Signaling Lymphocytic Activation Molecule Family
Descriptor Spanish: Familia de Moléculas Señalizadoras de la Activación Linfocitaria
Descriptor familia de moléculas señalizadoras de la activación linfocitaria
Entry term(s) moléculas señalizadoras de la activación linfocitaria
receptores SLAMF
receptores de la familia SLAM
receptores de la familia de moléculas señalizadoras de la activación linfocitaria
receptores de las moléculas señalizadoras de activación linfocitaria
Scope note: Glucoproteínas de membrana de tipo I que se expresan principalmente en la superficie de las CÉLULAS T CD4 o CD8-positivas, las CÉLULAS ASESINAS NATURALES y algunas poblaciones de CÉLULAS B. Se caracterizan por un DOMINIO SIMILAR A INMUNOGLOBULINA N-terminal extracelular y un DOMINIO DE INMUNOGLOBULINA C2 próximo a la membrana. Los receptores SLAMF típicamente señalizan mediante interacciones homofílicas y son importantes para mediar la respuesta inmunitaria y la diferenciación de las células inmunitarias.
Descriptor Portuguese: Família de Moléculas de Sinalização da Ativação Linfocitária
Descriptor French: Famille des molécules de signalisation de l'activation des lymphocytes
Entry term(s): SLAM Family Receptors
SLAMF Receptors
Signaling Lymphocytic Activation Molecule Family Receptors
Signaling Lymphocytic Activation Molecule Receptors
Signaling Lymphocytic Activation Molecules
Tree number(s): D09.400.430.890.736
D12.776.395.550.736
D12.776.543.550.746
D12.776.543.750.705.970
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071176
Scope note: Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Antigens, CD (1997-2016)
Receptors, Cell Surface (1997-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56632
Unique ID: D000071176
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2017/05/24
Signaling Lymphocytic Activation Molecule Family - Preferred
Concept UI M000613385
Scope note Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.
Preferred term Signaling Lymphocytic Activation Molecule Family
Entry term(s) SLAM Family Receptors
SLAMF Receptors
Signaling Lymphocytic Activation Molecule Family Receptors
Signaling Lymphocytic Activation Molecule Receptors
Signaling Lymphocytic Activation Molecules



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