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Descriptor English: MAP Kinase Signaling System
Descriptor Spanish: Sistema de Señalización de MAP Quinasas
Descriptor Portuguese: Sistema de Sinalização das MAP Quinases
Descriptor French: Système de signalisation des MAP kinases
Entry term(s): Cascade, MAP Kinase
ERK Pathway
ERK Pathways
ERK Signal Tranduction Pathway
ERK1 2 Pathway
ERK1 and ERK2 Pathway
ERK1-2 Pathway
ERK1-2 Pathways
JNK Pathway
JNK Pathways
JNK Signaling Pathway
JNK Signaling Pathways
Kinase Cascade, MAP
Kinase Pathway, p38
Kinase Pathways, p38
MAP Kinase Cascade
MAP Kinase Cascades
MAP Kinase Module
MAP Kinase Modules
MAP Kinase Signaling Cascades
MAP Kinase Signaling Pathways
MEK ERK Pathway
MEK-ERK Pathway
MEK-ERK Pathways
Module, MAP Kinase
Pathway, ERK
Pathway, ERK1-2
Pathway, JNK
Pathway, JNK Signaling
Pathway, MEK-ERK
Pathway, p38 Kinase
Pathways, ERK
Pathways, ERK1-2
Pathways, JNK
Pathways, JNK Signaling
Pathways, MEK-ERK
Pathways, p38 Kinase
Signaling Pathway, JNK
Signaling Pathways, JNK
p38 Kinase Pathway
p38 Kinase Pathways
p38 Kinase Signaling Pathway
Tree number(s): G02.111.820.560
G03.493.560
G04.835.560
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020935
Scope note: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1999)
Protein Kinases (1989-1999)
Protein-Serine-Threonine Kinases (1993-1999)
Protein-Tyrosine Kinase (1989-1999)
Public MeSH Note: 2000
History Note: 2000
Related: MAP Kinase Kinase Kinases MeSH
Mitogen-Activated Protein Kinase Kinases MeSH
Mitogen-Activated Protein Kinases MeSH
DeCS ID: 34468
Unique ID: D020935
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/05
Revision Date: 2016/06/23
MAP Kinase Signaling System - Preferred
Concept UI M0328035
Scope note An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Preferred term MAP Kinase Signaling System
ERK1-2 Pathway - Related but not broader or narrower
Concept UI M0555312
Preferred term ERK1-2 Pathway
Entry term(s) ERK1 2 Pathway
ERK1 and ERK2 Pathway
ERK1-2 Pathways
Pathway, ERK1-2
Pathways, ERK1-2
p38 Kinase Pathway - Narrower
Concept UI M0557375
Preferred term p38 Kinase Pathway
Entry term(s) Kinase Pathway, p38
Kinase Pathways, p38
Pathway, p38 Kinase
Pathways, p38 Kinase
p38 Kinase Pathways
p38 Kinase Signaling Pathway
MAP Kinase Cascade - Narrower
Concept UI M0331442
Preferred term MAP Kinase Cascade
Entry term(s) Cascade, MAP Kinase
Kinase Cascade, MAP
MAP Kinase Cascades
MAP Kinase Module
MAP Kinase Modules
MAP Kinase Signaling Cascades
Module, MAP Kinase
MAP Kinase Signaling Pathways - Related but not broader or narrower
Concept UI M0331445
Preferred term MAP Kinase Signaling Pathways
MEK-ERK Pathway - Narrower
Concept UI M0556022
Preferred term MEK-ERK Pathway
Entry term(s) MEK ERK Pathway
MEK-ERK Pathways
Pathway, MEK-ERK
Pathways, MEK-ERK
ERK Signal Tranduction Pathway - Narrower
Concept UI M0556021
Preferred term ERK Signal Tranduction Pathway
Entry term(s) ERK Pathway
ERK Pathways
Pathway, ERK
Pathways, ERK
JNK Pathway - Narrower
Concept UI M0557374
Preferred term JNK Pathway
Entry term(s) JNK Pathways
JNK Signaling Pathway
JNK Signaling Pathways
Pathway, JNK
Pathway, JNK Signaling
Pathways, JNK
Pathways, JNK Signaling
Signaling Pathway, JNK
Signaling Pathways, JNK



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