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Descriptor English: MAP Kinase Kinase Kinases
Descriptor Spanish: Quinasas Quinasa Quinasa PAM
Descriptor Portuguese: MAP Quinase Quinase Quinases
Descriptor French: MAP Kinase Kinase Kinases
Entry term(s): Kinase Kinase, MAPK-ERK
Kinase Kinases, MAPK-ERK
Kinase, MAP3
Kinase, MAPK-ERK Kinase
Kinase, MEK
Kinases, MAP Kinase Kinase
Kinases, MAP3
Kinases, MAPK-ERK Kinase
Kinases, MEK
MAP Kinase Kinase Kinase
MAP3 Kinase
MAP3 Kinases
MAPK ERK Kinase Kinase
MAPK ERK Kinase Kinases
MAPK-ERK Kinase Kinase
MAPK-ERK Kinase Kinases
MAPKKK
MAPKKKs
MEK Kinase
MEK Kinases
MEKK
MEKKs
Mitogen Activated Protein Kinase Kinase Kinase
Mitogen Activated Protein Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinase Kinase
Mitogen-Activated Protein Kinase Kinase Kinases
Tree number(s): D08.811.913.696.620.682.700.559
D12.644.360.400
D12.776.476.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020930
Scope note: Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.25
Previous Indexing: Protein Kinases (1989-1999)
Protein-Serine-Threonine Kinases (1993-1999)
Protein-Tyrosine Kinase (1989-1999)
Public MeSH Note: 2000; MAP KINASE KINASE KINASE (now MAP KINASE KINASE KINASES) was indexed under PROTEIN-SERINE-THREONINE KINASES (1992-1999)
History Note: 2000; use MAP KINASE KINASE KINASE (1992-1999)
Related: MAP Kinase Signaling System MeSH
DeCS ID: 34448
Unique ID: D020930
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2020/05/27
MAP Kinase Kinase Kinases - Preferred
Concept UI M0328033
Scope note Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
Preferred term MAP Kinase Kinase Kinases
Entry term(s) Kinase, MAP3
Kinases, MAP Kinase Kinase
Kinases, MAP3
MAP Kinase Kinase Kinase
MAP3 Kinase
MAP3 Kinases
MAPKKK
MAPKKKs
Mitogen Activated Protein Kinase Kinase Kinase
Mitogen Activated Protein Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinase Kinase
Mitogen-Activated Protein Kinase Kinase Kinases
MAPK-ERK Kinase Kinases - Narrower
Concept UI M0329022
Preferred term MAPK-ERK Kinase Kinases
Entry term(s) Kinase Kinase, MAPK-ERK
Kinase Kinases, MAPK-ERK
Kinase, MAPK-ERK Kinase
Kinase, MEK
Kinases, MAPK-ERK Kinase
Kinases, MEK
MAPK ERK Kinase Kinase
MAPK ERK Kinase Kinases
MAPK-ERK Kinase Kinase
MEK Kinase
MEK Kinases
MEKK
MEKKs



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