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Descriptor English: Phosphofructokinase-2
Descriptor Spanish: Fosfofructoquinasa-2
Descriptor fosfofructocinasa 2
Entry term(s) 6-fosfofructo-2-cinasa
6-fosfofructo-2-cinasa-fructosa-2,6-bisfosfatasa
6-fosfofructo-2-cinasa-fructosa-2,6-difosfatasa
PFK-2
fructosa-2,6-bisfosfatasa
fructosa-2,6-difosfatasa
Scope note: Enzima alostérica que regula la glicólisis y la gluconeogénesis catalizando la transferencia de un grupo fosfato del ATP a la fructosa-6-fosfato para producir fructosa-2,6-bisfosfato, un efector alostérica para la otra 6-fosfofructocinasa, la FOSFOFRUCTOCINASA 1. La fosfofructocinasa 2 tiene dos funciones: la forma desfosforilada es una cinasa y la forma fosforilada es una fosfatasa que escinde la fructosa-2,6-bisfosfato para producir fructosa-6-fosfato.
Descriptor Portuguese: Fosfofrutoquinase-2
Descriptor French: Phosphofructokinase-2
Entry term(s): 6-PF-2-K-Fru-2,6-P(2)ase
6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
6-Phosphofructo-2-kinase
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
6PF2K
ATP-D-Fructose-6-phosphate 2-phosphotransferase
F Kinase-F-bisphosphatase
Fru-6-P,2-kinase
Fru-kinase-Fru-bisphosphatase
Fructose 2,6-bisphosphatase
Fructose-2,6-bisphosphatase
Fructose-2,6-bisphosphate 2-phosphatase
Fructose-6-P,2-kinase
Fructose-6-phosphate,2-kinase
Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
Phosphofructokinase 2
fructose-2,6-diphosphatase
Tree number(s): D08.811.277.352.650.622
D08.811.641.843
D08.811.913.696.620.225.850.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D025481
Scope note: An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.1.105
Previous Indexing: Phosphofructokinase-1 (1981-2001)
Phosphoric Monoester Hydrolases (1983-2001)
Phosphotransferases (1981-2001)
Public MeSH Note: 2002; 6-PHOSPHOFRUCTO-2-KINASE was indexed under PHOSPHOTRANSFERASES (NM) 1993-2001, under PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; FRUCTOSE-2,6-BISPHOSPATASE was indexed under PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE was indexed under FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, under MULTIENZYME COMPLEXES (NM) 1990-2001, under PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001
History Note: 2002; for 6-PHOSPHOFRUCTO-2-KINASE use PHOSPHOTRANSFERASES (NM) 1993-2001, use PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; for FRUCTOSE-2,6-BISPHOSPATASE use PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; for 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE use FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, use MULTIENZYME COMPLEXES (NM) 1990-2001, use PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001
Related: Phosphofructokinase-1 MeSH
DeCS ID: 36081
Unique ID: D025481
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2013/07/08
Phosphofructokinase-2 - Preferred
Concept UI M0374774
Scope note An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
Preferred term Phosphofructokinase-2
Entry term(s) 6-Phosphofructo-2-kinase
6PF2K
ATP-D-Fructose-6-phosphate 2-phosphotransferase
Fru-6-P,2-kinase
Fructose-6-P,2-kinase
Fructose-6-phosphate,2-kinase
Phosphofructokinase 2
Fructose-2,6-bisphosphatase - Narrower
Concept UI M0105385
Preferred term Fructose-2,6-bisphosphatase
Entry term(s) Fructose 2,6-bisphosphatase
Fructose-2,6-bisphosphate 2-phosphatase
fructose-2,6-diphosphatase
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase - Broader
Concept UI M0166748
Preferred term 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
Entry term(s) 6-PF-2-K-Fru-2,6-P(2)ase
6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
F Kinase-F-bisphosphatase
Fru-kinase-Fru-bisphosphatase
Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase



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