DeCS

Descriptor English:

Debrisoquin

Descriptor Spanish:

Debrisoquina

Spanish from Spain

Descriptor	debrisoquina
Scope note:	Fármaco neuro-bloqueante adrenérgica similar en efectos a la GUANETIDINA. Hay que señalar también su función como sustrato de la enzima polimórfica del citocromo P-450. Personas con ciertas isoformas de esta enzima son incapaces de metabolizar adecuadamente esta y otras muchas sustancias clínicamente importantes. Se piensa que tiene un polimorfismo como el de la debrisoquina 4-hidroxilasa.

Descriptor Portuguese:

Debrisoquina

Descriptor French:

Débrisoquine

Tree number(s):

D03.633.100.531.205

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D003647

Scope note:

An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antihypertensive Agents
Sympatholytics
Adrenergic Agents

Registry Number:

X31CDK040E

CAS Type 1 Name:

2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-

DeCS ID:

3665

Unique ID:

D003647

Documents indexed in the Virtual Health Library (VHL):

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