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Descriptor English: Integrin alpha2beta1
Descriptor Spanish: Integrina alfa2beta1
Descriptor integrina alfa2beta1
Scope note: Integrina encontrada en los fibroblastos, plaquetas, células endoteliales y epiteiales, y linfocitos, donde funciona como un receptor para el COLÁGENO y la LAMININA. Aunque en un principio se habló del receptor del colágeno, se trata de uno de los diversos receptores del colágeno. El ligando unido a la integrina alfa2beta1 desencadena una cascada de señalización intracelular, incluida la activación de la cinasa p38 MAP.
Descriptor Portuguese: Integrina alfa2beta1
Descriptor French: Intégrine alpha2bêta1
Entry term(s): CD49b CD29
CD49b-CD29
Glycoprotein Ia IIa
Glycoprotein Ia-IIa
Late Antigen-2, Very
Platelet Membrane Glycoprotein Heterodimer Ia IIa
Platelet Membrane Glycoprotein Heterodimer Ia-IIa
VLA 2
VLA-2
Very Late Antigen 2
Very Late Antigen-2
alpha2beta1, Integrin
alpha2beta1Integrin
Tree number(s): D09.400.430.890.625.298
D12.776.395.550.625.298
D12.776.543.550.625.298
D12.776.543.750.685.200
D12.776.543.750.705.408.530.249
D12.776.543.750.705.408.850.199
D12.776.543.750.705.675.352
D12.776.543.750.705.876.280
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D038982
Scope note: An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Collagen Receptors (1991-2002)
Integrins (1994-2002)
Public MeSH Note: 2003; INTEGRIN ALPHA2BETA1 was indexed under INTEGRINS 1994-2002
History Note: 2003; for VLA-2 use COLLAGEN RECEPTORS (NM) 1991-2002; for PLATELET MEMBRANE GLYCOPROTEIN HETERODIMER IA-IIA use COLLAGEN RECEPTORS (NM) 1992-2000; for INTEGRIN ALPHA2BETA1 & CD49B-CD29 use COLLAGEN RECEPTORS (NM) 1994-2002; for ALPHA2BETA1INTEGRIN use COLLAGEN RECEPTORS (NM) 2001-2002
DeCS ID: 37449
Unique ID: D038982
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2016/06/17
Integrin alpha2beta1 - Preferred
Concept UI M0417889
Scope note An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Preferred term Integrin alpha2beta1
Entry term(s) CD49b CD29
CD49b-CD29
Glycoprotein Ia IIa
Glycoprotein Ia-IIa
Late Antigen-2, Very
Platelet Membrane Glycoprotein Heterodimer Ia IIa
Platelet Membrane Glycoprotein Heterodimer Ia-IIa
VLA 2
VLA-2
Very Late Antigen 2
Very Late Antigen-2
alpha2beta1, Integrin
alpha2beta1Integrin



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