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Descriptor English: Proteasome Endopeptidase Complex
Descriptor Spanish: Complejo de la Endopetidasa Proteasomal
Descriptor complejo de endopeptidasas de los proteasomas
Scope note: Gran complejo con múltiples subunidades que desempeña una función importante en la degradación de la mayoría de las proteínas citosólicas y nucleares de células eucarióticas. Contiene un subcomplejo catalítico de 700 kDa y dos subcomplejos regulatorios de 700 kDa. El complejo digiere proteínas ubiquitinadas y proteínas activadas a través de la antienzima ornitina-descarboxilasa.
Descriptor Portuguese: Complexo de Endopeptidases do Proteassoma
Descriptor French: Proteasome endopeptidase complex
Entry term(s): Complexe multicatalytique du protéasome
Complexe protéasique multicatalytique
Complexe protéinasique multicatalytique
Ingensin
Macroxyproteinase
Prosome
Protéase multicatalytique
Protéasome
Protéasome 20S
Tree number(s): D05.500.562.500
D08.811.277.656.918
D08.811.600.730
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D046988
Scope note: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Proteasome Inhibitors
Registry Number: EC 3.4.25.1
Related: Ubiquitin-protein ligase complexes MeSH
DeCS ID: 38685
Unique ID: D046988
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2012/07/03
Proteasome endopeptidase complex - Preferred
Concept UI M0140424
Preferred term Proteasome endopeptidase complex
Entry term(s) Complexe multicatalytique du protéasome
Complexe protéasique multicatalytique
Complexe protéinasique multicatalytique
Macroxyproteinase
Prosome
Protéase multicatalytique
Protéasome
Protéasome 20S
Ingensin - Narrower
Concept UI M0140417
Preferred term Ingensin



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