| Descriptor English: | Penicillin-Binding Proteins | ||||||
| Descriptor Spanish: | 
                                Proteínas de Unión a las Penicilinas                                        
                                        
                                                                                                                            
                                            
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| Descriptor Portuguese: | Proteínas de Ligação às Penicilinas | ||||||
| Descriptor French: | Protéines de liaison aux pénicillines | ||||||
| Entry term(s): | 
                                    Penicillin Binding Protein Penicillin Binding Protein 1 Penicillin Binding Protein 1A Penicillin Binding Protein 1b Penicillin Binding Protein 2 Penicillin Binding Protein 2a Penicillin Binding Protein 2b Penicillin Binding Protein 3 Penicillin Binding Protein 4 Penicillin Binding Protein 5 Penicillin Binding Protein 6 Penicillin Binding Protein 7 Penicillin Binding Proteins Penicillin-Binding Protein Penicillin-Binding Protein 1 Penicillin-Binding Protein 1A Penicillin-Binding Protein 1b Penicillin-Binding Protein 2 Penicillin-Binding Protein 2a Penicillin-Binding Protein 2b Penicillin-Binding Protein 3 Penicillin-Binding Protein 4 Penicillin-Binding Protein 5 Penicillin-Binding Protein 6 Penicillin-Binding Protein 7 Penicillin-Binding Protein-2a Peptidoglycan Synthetase Protein 1A, Penicillin-Binding Protein 1b, Penicillin-Binding Proteins, Penicillin-Binding Synthetase, Peptidoglycan  | 
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| Tree number(s): | 
                                        D08.811.710 D12.776.097.545  | 
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D046915 | ||||||
| Scope note: | Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES. | 
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| Allowable Qualifiers: | 
                                                                        AD                                                            administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine  | 
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| Previous Indexing: | 
                                                Bacterial Proteins (1978-2004) Carrier Proteins (1978-2004) Hexosyltransferases (1999-2004) Muramoylpentapeptide Carboxypeptidase (1978-2004) Peptidyltransferase (1978-2004)  | 
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| Public MeSH Note: | 2005; PENICILLIN-BINDING PROTEINS was indexed under HEXOSYLTRANSFERASES 1999-2004, under BACTERIAL PROTEINS, MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; CARRIER PROTEINS, & PEPTIDYLTRANSFERASE 1978-2004 | 
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| History Note: | 2005 (1978); | 
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| Related: | 
                                                                                                                        Hexosyltransferases
                                            MeSH                                             Muramoylpentapeptide Carboxypeptidase MeSH Peptidyl Transferases MeSH  | ||||||
| DeCS ID: | 38704 | ||||||
| Unique ID: | D046915 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2005/01/01 | ||||||
| Date of Entry: | 2004/07/08 | ||||||
| Revision Date: | 2013/07/09 | 
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                                        CHEMICALS AND DRUGS
 
Enzymes and Coenzymes [D08]Enzymes and Coenzymes - 
                                    
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins 
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                        Penicillin-Binding Proteins                                            
                                        - Preferred                                        
                                                                
                                
                        
                        
                        
                                                                    
                        Penicillin-Binding Protein 1A                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 1b                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 2                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 2a                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Peptidoglycan Synthetase                                            
                                        - Related but not broader or narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 3                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 4                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 5                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 6                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 7                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 1                                            
                                        - Narrower                                        
                                                                
                                
                                                                    
                        Penicillin-Binding Protein 2b                                            
                                        - Narrower                                        
                                                                
                                
                        
                        
                    
                    
                
                | Concept UI | 
                                        
                                        M0068526 | 
                                
| Scope note | Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES. | 
| Preferred term | Penicillin-Binding Proteins | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein                                                 Penicillin Binding Proteins Penicillin-Binding Protein Proteins, Penicillin-Binding  | 
                                
| Concept UI | 
                                        
                                        M0107496 | 
                                
| Preferred term | Penicillin-Binding Protein 1A | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 1A                                                 Protein 1A, Penicillin-Binding  | 
                                
| Concept UI | 
                                        
                                        M0107498 | 
                                
| Preferred term | Penicillin-Binding Protein 1b | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 1b                                                 Protein 1b, Penicillin-Binding  | 
                                
| Concept UI | 
                                        
                                        M0107499 | 
                                
| Preferred term | Penicillin-Binding Protein 2 | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 2                                                 | 
                                
| Concept UI | 
                                        
                                        M0068523 | 
                                
| Preferred term | Penicillin-Binding Protein 2a | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 2a                                                 Penicillin-Binding Protein-2a  | 
                                
| Concept UI | 
                                        
                                        M0107502 | 
                                
| Scope note | A complex of enzymes that synthesize the peptidoglycan cell wall structure. | 
| Preferred term | Peptidoglycan Synthetase | 
| Entry term(s) | 
                                        
                                                                                            Synthetase, Peptidoglycan                                                 | 
                                
| Concept UI | 
                                        
                                        M0107500 | 
                                
| Preferred term | Penicillin-Binding Protein 3 | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 3                                                 | 
                                
| Concept UI | 
                                        
                                        M0068524 | 
                                
| Preferred term | Penicillin-Binding Protein 4 | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 4                                                 | 
                                
| Concept UI | 
                                        
                                        M0068521 | 
                                
| Preferred term | Penicillin-Binding Protein 5 | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 5                                                 | 
                                
| Concept UI | 
                                        
                                        M0068518 | 
                                
| Preferred term | Penicillin-Binding Protein 6 | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 6                                                 | 
                                
| Concept UI | 
                                        
                                        M0068522 | 
                                
| Preferred term | Penicillin-Binding Protein 7 | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 7                                                 | 
                                
| Concept UI | 
                                        
                                        M0068519 | 
                                
| Preferred term | Penicillin-Binding Protein 1 | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 1                                                 | 
                                
| Concept UI | 
                                        
                                        M0454417 | 
                                
| Preferred term | Penicillin-Binding Protein 2b | 
| Entry term(s) | 
                                        
                                                                                            Penicillin Binding Protein 2b                                                 | 
                                
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