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Descriptor English: Deoxyribonuclease I
Descriptor Spanish: Desoxirribonucleasa I
Descriptor desoxirribonucleasa I
Entry term(s) DNasa I
estreptodornasa
Scope note: Enzima que es capaz de hidrolizar ADN altamente polimerizado escindiendo los enlaces fosfodiéster, preferentemente los adyacentes a un nucleótido pirimidínico. Cataliza la escisión endonucleolítica del ADN dando lugar a los productos finales 5'-fosfodinucleótidos y oligonucleótidos. La enzima tiene preferencia por el ADN bicatenario.
Descriptor Portuguese: Desoxirribonuclease I
Descriptor French: Deoxyribonuclease I
Entry term(s): DNA Endonuclease
DNA Nicking Enzyme
DNAase I
DNase I
DNase, Pancreatic
Dornavac
Endonuclease I
Endonuclease, DNA
Nickase
Pancreatic DNase
Streptodornase
T4 Endonuclease II
T4-Endonuclease II
T7 Endonuclease I
T7-Endonuclease I
Thymonuclease
Tree number(s): D08.811.277.352.335.350.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003850
Scope note: An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Annotation: do not confuse entry term STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.21.1
Previous Indexing: Deoxyribonucleases (1966-1982)
Endodeoxyribonucleases (1983-1984)
Endonucleases (1973-1982)
Public MeSH Note: 85; STREPTORDORNASE was see DEOXYRIBONUCLEASES 1966-93
Online Note: use DEOXYRIBONUCLEASES to search STREPTODORNASE 1966-93
History Note: 85; STREPTODORNASE was see DEOXYRIBONUCLEASES 1966-93
DeCS ID: 3873
Unique ID: D003850
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1985/01/01
Date of Entry: 1984/05/24
Revision Date: 2003/07/09
Deoxyribonuclease I - Preferred
Concept UI M0006007
Scope note An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Preferred term Deoxyribonuclease I
Entry term(s) DNA Endonuclease
DNAase I
DNase I
DNase, Pancreatic
Endonuclease, DNA
Pancreatic DNase
Thymonuclease
Nickase - Related but not broader or narrower
Concept UI M0006010
Preferred term Nickase
Entry term(s) DNA Nicking Enzyme
Endonuclease I
T4-Endonuclease II - Related but not broader or narrower
Concept UI M0006009
Preferred term T4-Endonuclease II
Entry term(s) T4 Endonuclease II
T7-Endonuclease I - Related but not broader or narrower
Concept UI M0006011
Preferred term T7-Endonuclease I
Entry term(s) T7 Endonuclease I
Dornavac - Narrower
Concept UI M0372342
Preferred term Dornavac
Streptodornase - Related but not broader or narrower
Concept UI M0006008
Preferred term Streptodornase



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