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Descriptor English: DNA Polymerase I
Descriptor Spanish: ADN Polimerasa I
Descriptor ADN polimerasa I
Entry term(s) ADN polimerasa I dependiente de ADN
ADN polimerasa alfa
DNA polimerasa I
DNA polimerasa I dependiente de DNA
DNA polimerasa alfa
fragmento Klenow
pol I
Scope note: ADN-polimerasa dependiente de ADN identificada en procariotas que puede estar presente en organismos superiores. Tiene actividad exonucleasa de 3'-5' y de 5'-3', pero no puede usar ADN bicatenario nativo como molde cebador. No es inhibida por reactivos sulfhidrílicos y es activa tanto en la síntesis como en la reparación del ADN.
Descriptor Portuguese: DNA Polimerase I
Descriptor French: DNA polymerase I
Entry term(s): DNA Dependent DNA Polymerase I
DNA Pol I
DNA Polymerase alpha
DNA-Dependent DNA Polymerase I
Klenow Fragment
Polymerase I, DNA
Polymerase alpha, DNA
Tree number(s): D08.811.913.696.445.308.300.225
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004256
Scope note: A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.7.7
Previous Indexing: DNA Nucleotidyltransferases (1968-1976)
Public MeSH Note: 84; see DNA POLYMERASES 1977-83; for DNA POLYMERASE ALPHA see DNA POLYMERASE II 1982-97
History Note: 84(77); for DNA POLYMERASE ALPHA use DNA POLYMERASE II 1982-97
DeCS ID: 4323
Unique ID: D004256
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1976/04/21
Revision Date: 2020/06/22
DNA Polymerase I - Preferred
Concept UI M0006661
Scope note A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair.
Preferred term DNA Polymerase I
Entry term(s) DNA Dependent DNA Polymerase I
DNA Pol I
DNA Polymerase alpha
DNA-Dependent DNA Polymerase I
Klenow Fragment
Polymerase I, DNA
Polymerase alpha, DNA



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