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Descriptor English: DNA Polymerase III
Descriptor Spanish: ADN Polimerasa III
Descriptor ADN polimerasa III
Entry term(s) ADN polimerasa III dependiente de ADN
ADN polimerasa delta
DNA polimerasa III DNA-dependiente
DNA polimerasa III dependiente de DNA
DNA polimerasa delta
pol III
Scope note: ADN-polimerasa dependiente de ADN, descrita en E. coli y en otros organismos inferiores, pero puede estar presente en organismos superiores. Nombre utilizado también para referirse a una forma más compleja de ADN-polimerasa III, designada como ADN-polimerasa III* o pol III*, que es 15 veces más activa biológicamente que la ADN-polimerasa I en la síntesis de ADN. Esta polimerasa tiene actividad de exonucleasa tanto 3'-5'como 5'-3', es inhibida por reactivos sulfhidrílicos y tiene la misma dependencia molde-cebador que la pol II.
Descriptor Portuguese: DNA Polimerase III
Descriptor French: DNA polymerase III
Entry term(s): DNA Dependent DNA Polymerase III
DNA Pol III
DNA Polymerase delta
DNA-Dependent DNA Polymerase III
Polymerase III, DNA
Polymerase delta, DNA
Tree number(s): D08.811.913.696.445.308.300.235
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004258
Scope note: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.7.7
Previous Indexing: DNA Nucleotidyltransferases (1968-1976)
Public MeSH Note: 91; see DNA POLYMERASES 1977-90, DNA POLYMERASE DELTA was indexed under DNA POLYMERASES 1980-97
History Note: 91(77); for DNA POLYMERASE DELTA use DNA POLYMERASE III (NM) 1980-97
DeCS ID: 4325
Unique ID: D004258
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1976/04/21
Revision Date: 2020/06/22
DNA Polymerase III - Preferred
Concept UI M0006663
Scope note A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II.
Preferred term DNA Polymerase III
Entry term(s) DNA Dependent DNA Polymerase III
DNA Pol III
DNA Polymerase delta
DNA-Dependent DNA Polymerase III
Polymerase III, DNA
Polymerase delta, DNA



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