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Descriptor English: DNA Polymerase II
Descriptor Spanish: ADN Polimerasa II
Descriptor ADN polimerasa II
Entry term(s) ADN polimerasa II dependiente de ADN
ADN polimerasa epsilon
DNA polimerasa II DNA-dependiente
DNA polimerasa II dependiente de DNA
DNA polimerasa epsilon
pol II
Scope note: ADN-polimerasa dependiente de ADN, descrita en E. coli y en otros organismos inferiores. Puede estar presente en organismos superiores y tiene una actividad molecular intrínseca de sólo el 5 % respecto de la actividad de la ADN-polimerasa I. Esta polimerasa tiene actividad de exonucleasa 3'-5', actúa solo sobre el ADN bicatenario con espacios o en los terminales de cadena única de menos de 100 nucleótidos como molde, y resulta inhibida por reactivos sulfhidrílicos.
Descriptor Portuguese: DNA Polimerase II
Descriptor French: DNA polymerase II
Entry term(s): DNA Dependent DNA Polymerase II
DNA Pol II
DNA Polymerase epsilon
DNA-Dependent DNA Polymerase II
Tree number(s): D08.811.913.696.445.308.300.230
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004257
Scope note: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.7.7
Previous Indexing: DNA Nucleotidyltransferases (1968-1976)
Public MeSH Note: 84; see DNA POLYMERASES 1977-83; DNA POLYMERASE EPSILON was indexed under DNA POLYMERASES 1994-97
History Note: 84(77); for DNA POLYMERASE EPSILON use DNA POLYMERASE II (NM) 1994-97
DeCS ID: 4324
Unique ID: D004257
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1976/04/21
Revision Date: 2020/06/22
DNA Polymerase II - Preferred
Concept UI M0006662
Scope note A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents.
Preferred term DNA Polymerase II
Entry term(s) DNA Dependent DNA Polymerase II
DNA Pol II
DNA Polymerase epsilon
DNA-Dependent DNA Polymerase II



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