| Descriptor English: | DNA Polymerase iota | ||||||
| Descriptor Spanish: |
ADN Polimerasa iota
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| Descriptor Portuguese: | DNA Polimerase iota | ||||||
| Descriptor French: | Without translation | ||||||
| Entry term(s): |
POL iota POLiota RAD30B |
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| Tree number(s): |
D08.811.913.696.445.308.300.493 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000094769 | ||||||
| Scope note: | A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in translesion DNA synthesis. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.7.7 | ||||||
| Public MeSH Note: | 2023; was indexed as DNA-DIRECTED DNA POLYMERASE 2000-2022 |
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| History Note: | 2023 (2000) |
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| DeCS ID: | 60292 | ||||||
| Unique ID: | D000094769 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2023/01/01 | ||||||
| Date of Entry: | 2022/07/13 | ||||||
| Revision Date: | 2022/07/12 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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DNA Polymerase iota
- Preferred
| Concept UI |
M0372410 |
| Scope note | A highly error-prone DNA polymerase. It is a member of the Y-family of DNA polymerases that are DNA DAMAGE tolerant and involved in translesion DNA synthesis. DNA polymerase iota is an orthologue of yeast Rad30. Its replication fidelity is template dependent and favors Hoogsteen base-pairing at its active site. |
| Preferred term | DNA Polymerase iota |
| Entry term(s) |
POL iota POLiota RAD30B |
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