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Descriptor English: Protein Tyrosine Phosphatase, Non-Receptor Type 1
Descriptor Spanish: Proteína Tirosina Fosfatasa no Receptora Tipo 1
Descriptor proteína tirosina fosfatasa no receptora de tipo 1
Scope note: Subtipo de proteína tirosina fosfatasas no receptoras que incluye dos motivos de direccionamiento distintivos: un motivo N-terminal específico del RECEPTOR DE LA INSULINA, y un motivo C-terminal específico de las proteínas que contienen el dominio SH3. Este subtipo incluye un dominio hidrófobo que lo localiza en el RETÍCULO ENDOPLÁSMICO.
Descriptor Portuguese: Proteína Tirosina Fosfatase não Receptora Tipo 1
Descriptor French: Protein Tyrosine Phosphatase, Non-Receptor Type 1
Entry term(s): PTPase 1B
PTPase HA2
Protein Tyrosine Phosphatase 1B
Protein Tyrosine Phosphatase HA2
Protein Tyrosine Phosphatase, Non Receptor Type 1
Protein-Tyrosine Phosphatase HA2
Tree number(s): D08.811.277.352.650.775.300.100
D12.776.476.564.300.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054562
Scope note: A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.3.48
Previous Indexing: Protein Tyrosine Phosphatases (1991-2007)
Public MeSH Note: 2008; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 was indexed under PROTEIN TYROSINE PHOSPHATASES 2000-2007, and under MEMBRANE PROTEINS & PROTEIN TYROSINE PHOSPHATASES 1999-2000; for PTPase 1B see PROTEIN-TYROSINE-PHOSPHATASE 1991-2007
History Note: 2008
DeCS ID: 52696
Unique ID: D054562
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2015/11/24
Protein Tyrosine Phosphatase, Non-Receptor Type 1 - Preferred
Concept UI M0331760
Scope note A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.
Preferred term Protein Tyrosine Phosphatase, Non-Receptor Type 1
Entry term(s) PTPase 1B
PTPase HA2
Protein Tyrosine Phosphatase 1B
Protein Tyrosine Phosphatase HA2
Protein Tyrosine Phosphatase, Non Receptor Type 1
Protein-Tyrosine Phosphatase HA2



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