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Descriptor English: Protein Tyrosine Phosphatase, Non-Receptor Type 22
Descriptor Spanish: Proteína Tirosina Fosfatasa no Receptora Tipo 22
Descriptor proteína tirosina fosfatasa no receptora de tipo 22
Scope note: Subtipo de proteína tirosina fosfatasas no receptoras que se caracteriza por la presencia de un dominio catalítico N terminal y de un dominio C terminal rico en PROLINA. El subtipo de fosfatasa se expresa de modo predominante en los LINFOCITOS y desempeña un papel importante en la inhibición de la activación de la linea de LINFOCITOS T. Los polimorfismos en el gene que codifican este subtipo de fosfatasa se asocian a varias ENFERMEDADES AUTOINMUNES.
Descriptor Portuguese: Proteína Tirosina Fosfatase não Receptora Tipo 22
Descriptor French: Protein Tyrosine Phosphatase, Non-Receptor Type 22
Entry term(s): Lymphoid Phosphatase
Lyp1 PTPase
Lyp2 PTPase
PTPN 22 Protein
PTPN-22 Protein
PTPase Lyp
PTPase, Lyp1
PTPase, Lyp2
Protein Tyrosine Phosphatase Lyp
Protein Tyrosine Phosphatase, Non Receptor Type 22
Protein-Tyrosine Phosphatase Lyp
Tyrosine Protein Phosphatase, Non Receptor Type 22
Tyrosine Protein Phosphatase, Non-Receptor Type 22
Tree number(s): D08.811.277.352.650.775.300.930
D12.776.476.564.300.930
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054596
Scope note: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.3.48
Public MeSH Note: 2008; TYROSINE PROTEIN PROSPHATASE, NON-RECEPTOR TYPE 22 was indexed under PROTEIN TYROSINE PHOSPHATASES 1999-2007
History Note: 2008(1999)
DeCS ID: 52703
Unique ID: D054596
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2016/04/15
Protein Tyrosine Phosphatase, Non-Receptor Type 22 - Preferred
Concept UI M0302581
Scope note A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
Preferred term Protein Tyrosine Phosphatase, Non-Receptor Type 22
Entry term(s) Lymphoid Phosphatase
PTPN 22 Protein
PTPN-22 Protein
PTPase Lyp
Protein Tyrosine Phosphatase Lyp
Protein Tyrosine Phosphatase, Non Receptor Type 22
Protein-Tyrosine Phosphatase Lyp
Tyrosine Protein Phosphatase, Non Receptor Type 22
Tyrosine Protein Phosphatase, Non-Receptor Type 22
Lyp1 PTPase - Narrower
Concept UI M0302578
Scope note An alternatively spliced variant of tyrosine protein phosphatase, non-receptor type 22.
Preferred term Lyp1 PTPase
Entry term(s) PTPase, Lyp1
Lyp2 PTPase - Narrower
Concept UI M0302579
Scope note An alternatively spliced variant of tyrosine protein phosphatase, non-receptor type 22.
Preferred term Lyp2 PTPase
Entry term(s) PTPase, Lyp2



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