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Descriptor English: Protein Tyrosine Phosphatase, Non-Receptor Type 12
Descriptor Spanish: Proteína Tirosina Fosfatasa no Receptora Tipo 12
Descriptor proteína tirosina fosfatasa no receptora de tipo 12
Scope note: Subtipo de proteína tirosina fosfatasas no receptoras que se caracteriza por la presencia de un dominio catalítico N-terminal y un gran dominio C-terminal que es rico en residuos de PROLINA, ÁCIDO GLUTÁMICO, SERINA y TREONINA (secuencias PEST). El subtipo de fosfatasa se expresa de modo ubicuo e interviene en la regulación de diversos procesos biológicos, como el MOVIMIENTO CELULAR, la CITOQUIINESIS, el desensamblaje de la adhesión focal y la ACTIVACIÓN DE LINFOCITOS.
Descriptor Portuguese: Proteína Tirosina Fosfatase não Receptora Tipo 12
Descriptor French: Protein Tyrosine Phosphatase, Non-Receptor Type 12
Entry term(s): PEP PTPase
PEP Protein Tyrosine Phosphatase
PEST Enriched Phosphatase
PEST-Enriched Phosphatase
PTP-PEST
PTPase, PEP
Phosphatase, PEST-Enriched
Protein Tyrosine Phosphatase, Non Receptor Type 12
Tree number(s): D08.811.277.352.650.775.300.850
D12.776.476.564.300.850
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054594
Scope note: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.3.48
Public MeSH Note: 2008; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 12 was indexed under PROTEIN TYROSINE PHOSPHATASE 1994-2007
History Note: 2008(1994)
DeCS ID: 52701
Unique ID: D054594
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2015/11/24
Protein Tyrosine Phosphatase, Non-Receptor Type 12 - Preferred
Concept UI M0232435
Scope note A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
Preferred term Protein Tyrosine Phosphatase, Non-Receptor Type 12
Entry term(s) PEP PTPase
PEP Protein Tyrosine Phosphatase
PEST Enriched Phosphatase
PEST-Enriched Phosphatase
PTP-PEST
PTPase, PEP
Phosphatase, PEST-Enriched
Protein Tyrosine Phosphatase, Non Receptor Type 12



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