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Descriptor English: Ferrochelatase
Descriptor Spanish: Ferroquelatasa
Descriptor ferroquelatasa
Entry term(s) hemo sintetasa
porfirina-metal quelatasa
Scope note: Enzima mitocondrial de una gran variedad de células y tejidos. Es la enzima final en la via biosintética de 8-enzimas del HEMO. La ferroquelatasa cataliza la inserción ferrosa en la protoporfirina IX para forma protohemo o hemo. La deficiencia de esta enzima da lugar a la PROTOPORFIRIA ERITROPOYÉTICA.
Descriptor Portuguese: Ferroquelatase
Descriptor French: Ferrochelatase
Entry term(s): Chelatase, Porphyrin-Metal
Chelatase, Zinc
Ferro-Lyase, Protoheme
Heme Synthetase
Porphyrin Metal Chelatase
Porphyrin-Metal Chelatase
Protoheme Ferro Lyase
Protoheme Ferro-Lyase
Synthetase, Heme
Zinc Chelatase
Tree number(s): D08.811.520.500
D12.776.157.427.374.375.957
D12.776.556.579.374.375.617
D12.776.575.562
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005294
Scope note: A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Protoporphyria, Erythropoietic
Registry Number: EC 4.99.1.1
CAS Type 1 Name: Protoheme ferro-lyase
Previous Indexing: Iron (1966-1976)
Lyases (1966-1976)
Porphyrins (1966-1976)
Protoporphyrins (1975-1976)
Public MeSH Note: 1991; see LYASES 1977-1990
History Note: 1991(1977); use LYASES 1977-1990
DeCS ID: 5403
Unique ID: D005294
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1976/04/27
Revision Date: 2011/06/24
Ferrochelatase - Preferred
Concept UI M0008356
Scope note A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Preferred term Ferrochelatase
Entry term(s) Chelatase, Porphyrin-Metal
Ferro-Lyase, Protoheme
Heme Synthetase
Porphyrin Metal Chelatase
Porphyrin-Metal Chelatase
Protoheme Ferro Lyase
Protoheme Ferro-Lyase
Synthetase, Heme
Zinc Chelatase - Narrower
Concept UI M0008357
Preferred term Zinc Chelatase
Entry term(s) Chelatase, Zinc



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