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Descriptor English: Filamins
Descriptor Spanish: Filaminas
Descriptor filaminas
Scope note: Familia de proteínas filamentosas que se entrecruzan, codificadas por diversos genes FLN. Las filaminas están relacionadas con la adhesión, la expansión y la migración celulares, actuando como estructura para alrededor de 90 tipos de unión, incluidos canales, receptores, moléculas de señalización celular y factores de trascripción. Debido a la amplitud de interacciones moleculares, las mutaciones en los genes FLN tienen consecuencias desde moderadas hasta letales.
Descriptor Portuguese: Filaminas
Descriptor French: Filamines
Entry term(s): 1-Like Protein, Filamin
1-Like Proteins, Filamin
280 kDa Actin Binding Protein
280 kDa Actin-Binding Protein
Cs, Filamin
Filamin
Filamin 1
Filamin 1 Like Protein
Filamin 1-Like Protein
Filamin 1-Like Proteins
Filamin A
Filamin B
Filamin C
Filamin Cs
Merofilamin
Merofilamins
Protein, Filamin 1-Like
Proteins, Filamin 1-Like
alpha Filamin
alpha-Filamin
alpha-Filamins
beta Filamin
beta-Filamin
beta-Filamins
Tree number(s): A11.284.430.214.190.750.050.414
D05.750.078.730.315
D12.776.210.249
D12.776.220.525.315
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064448
Scope note: A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2014; was indexed under CONTRACTILE PROTEINS and MICROFILAMENT PROTEINS 1977-2013.
History Note: 2014
DeCS ID: 55183
Unique ID: D064448
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2016/06/28
Filamins - Preferred
Concept UI M0061356
Scope note A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
Preferred term Filamins
Entry term(s) Filamin
Filamin B - Narrower
Concept UI M0491334
Preferred term Filamin B
Entry term(s) 1-Like Protein, Filamin
1-Like Proteins, Filamin
Filamin 1 Like Protein
Filamin 1-Like Protein
Filamin 1-Like Proteins
Protein, Filamin 1-Like
Proteins, Filamin 1-Like
beta Filamin
beta-Filamin
beta-Filamins
Merofilamins - Narrower
Concept UI M0061355
Preferred term Merofilamins
Entry term(s) Merofilamin
Filamin A - Narrower
Concept UI M0491333
Preferred term Filamin A
Entry term(s) 280 kDa Actin Binding Protein
280 kDa Actin-Binding Protein
Filamin 1
alpha Filamin
alpha-Filamin
alpha-Filamins
Filamin C - Narrower
Concept UI M0581937
Preferred term Filamin C
Entry term(s) Cs, Filamin
Filamin Cs



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